{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T17:36:09Z","timestamp":1780940169959,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T00:00:00Z","timestamp":1446595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004271","name":"Sapienza University of Rome","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006747","name":"Fondazione Cariverona","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006747","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:label\/><jats:p>Family history of dementia (FH) is a recognized risk factor for developing late\u2010onset Alzheimer's disease (AD). We asked whether having FH increases AD risk and influences disease severity (age at onset and cognitive impairment) in 420 AD patients and 109 controls with (FH+) or without (FH\u2212). The relationships of APOE and other AD risk genes with FH were analyzed as well. The proportion of APOE e4 allele carriers was higher among the FH+ than the FH\u2212 AD patients (49.6% vs. 38.9%; <jats:italic>P\u2009<\/jats:italic>=\u20090.04). The distribution of the risk genotypes of nine AD susceptibility genes previously examined (CHAT, CYP17, CYP19, ESR1, FSHR, P53, P73, P21, PPARG) did not differ between the FH+ and the FH\u2212 AD patients, indicating that none contributed significantly to familial clustering of disease. FH was associated with an increased AD risk (odds ratio [OR] 2.71, 95% confidence interval [CI] 1.44\u20135.09; <jats:italic>P\u2009<\/jats:italic>=\u20090.002) independent of carrying the APOE e4 allele (OR 2.61, 95%CI 1.53\u20134.44; <jats:italic>P\u2009<\/jats:italic>=\u20090.0004). Having a first\u2010degree relative or a parent with dementia was significantly associated with AD risk (OR 2.9, 95%CI 1.3\u20136.4; <jats:italic>P\u2009<\/jats:italic>=\u20090.009 and OR 2.7, 95%CI 1.1\u20136.2; <jats:italic>P\u2009<\/jats:italic>=\u20090.02) but having a sibling with dementia was not (OR 1.7, 95%CI 0.2 to 14.7; <jats:italic>P\u2009<\/jats:italic>=\u20090.6). Among the FH+ AD patients, having one or both parents affected seemed to raise the risk of earlier onset age (<jats:italic>P\u2009<\/jats:italic>=\u20090.02) and greater cognitive impairment (<jats:italic>P\u2009<\/jats:italic>=\u20090.02) than having only an affected sibling, whereas having two or more affected relatives did not. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.b.32399","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T12:09:55Z","timestamp":1446638995000},"page":"250-256","source":"Crossref","is-referenced-by-count":56,"title":["Influence of family history of dementia in the development and progression of late\u2010onset Alzheimer's disease"],"prefix":"10.1002","volume":"171","author":[{"given":"Daniela","family":"Scarabino","sequence":"first","affiliation":[{"name":"CNR Institute of Cellular Biology and Neurobiology, Monterotondo Scalo, Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Gambina","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Alzheimer's Disease Center, University and Hospital of Verona, Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Broggio","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Alzheimer's Disease Center, University and Hospital of Verona, Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franca","family":"Pelliccia","sequence":"additional","affiliation":[{"name":"Department of Biology and Biotechnology \u201cCharles Darwin,\u201d Sapienza University, Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Maria","family":"Corbo","sequence":"additional","affiliation":[{"name":"Department of Biology and Biotechnology \u201cCharles Darwin,\u201d Sapienza University, Rome Italy"},{"name":"Department of Biology and Biotechnology \u201cCharles Darwin,\u201d CNR Institute of Molecular Biology and Pathology, Sapienza University, Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,4]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"American Psychiatric Association.1994. 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