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Several studies have reported telomere dysfunction in schizophrenia, and common variants in the telomerase reverse transcriptase (<jats:italic>TERT<\/jats:italic>) gene. <jats:italic>TERT<\/jats:italic> is a key component of the telomerase complex that maintains telomere length by addition of telomere repeats to telomere ends, and has repeatedly shown association with mean lymphocyte telomere length (LTL). Thus, we hypothesized that <jats:italic>TERT<\/jats:italic> may be a novel susceptibility gene for schizophrenia. Using a Taqman protocol, we genotyped eight tag SNPs from the <jats:italic>TERT<\/jats:italic> locus in 1,072 patients with paranoid schizophrenia and 1,284 control subjects from a Chinese Han population. We also measured mean LTL in 98 cases and 109 controls using a quantitative PCR\u2010based technique. Chi\u2010square tests showed that two SNPs, rs2075786 (<jats:italic>P<\/jats:italic>\u2009=\u20090.0009, OR\u2009=\u20090.76, 95%CI\u2009=\u20090.65\u20130.90) and rs4975605 (<jats:italic>P<\/jats:italic>\u2009=\u20090.0026, OR\u2009=\u20090.73, 95%CI\u2009=\u20090.60\u20130.90), were associated with a protective effect, while rs10069690 was associated with risk of paranoid schizophrenia (<jats:italic>P<\/jats:italic>\u2009=\u20090.0044, OR\u2009=\u20091.23, 95%CI\u2009=\u20091.07\u20131.42). Additionally, the rs2736118\u2010rs2075786 haplotype showed significant association with paranoid schizophrenia (<jats:italic>P<\/jats:italic>\u2009=\u20090.0013). Moreover, mean LTL correlated with rs2075786 genotypes was significantly shorter in the patient group than the control group. The present results suggest that the <jats:italic>TERT<\/jats:italic> gene may be a novel candidate involved in the development of paranoid schizophrenia. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.b.32403","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T14:33:24Z","timestamp":1453473204000},"page":"317-324","source":"Crossref","is-referenced-by-count":28,"title":["Variants in <i>TERT<\/i> influencing telomere length are associated with paranoid schizophrenia risk"],"prefix":"10.1002","volume":"171","author":[{"given":"Shuquan","family":"Rao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences &amp; Peking Union Medical College Tsinghua University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Ye","sequence":"additional","affiliation":[{"name":"State 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