{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:15:57Z","timestamp":1790702157076,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T00:00:00Z","timestamp":1448841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:label\/><jats:p>Much remains to be learned about the etiology of obsessive\u2010compulsive disorder (OCD). Twin studies suggest that it arises from both disorder\u2010specific and non\u2010specific genetic factors. To understand the etiology of OCD per se, it is necessary to identify disorder\u2010specific factors. Previous research shows that OCD is associated with serotonin\u2010related polymorphisms (<jats:italic>5\u2010HTTLPR<\/jats:italic> coded as triallelic and <jats:italic>HTR2A<\/jats:italic> rs6311\/rs6313) and, in males, a polymorphism involved in catecholamine modulation; <jats:italic>COMT<\/jats:italic> (rs4680). The present study is the first comprehensive meta\u2010analysis to investigate whether these polymorphisms are specific to OCD. A meta\u2010analysis was conducted for genetic association studies of OCD or any other psychiatric disorder, published in any language, in any country. A total of 551 studies were examined, of which 290 were included, consisting of 47,358 cases and 68,942 controls from case control studies, and 2,443 trios from family based studies. The main meta\u2010analysis was limited to those disorders in which there were at least five datasets (studies or sub\u2010studies) per disorder. Results confirmed that OCD is associated with polymorphisms of <jats:italic>5\u2010HTTLPR<\/jats:italic>, <jats:italic>HTR2A<\/jats:italic>, and, in males only, <jats:italic>COMT<\/jats:italic>. These polymorphisms were not associated with almost all other forms of psychopathology, including unipolar mood disorders, bipolar disorder, panic disorder, schizophrenia, and alcohol dependence. OCD, compared to most other disorders, had a significantly stronger association with particular alleles of each of the polymorphisms. Results did not differ across ancestral groups (Asian vs. Caucasian), designs (case control vs. family based), or diagnostic systems. Results suggest that the polymorphisms investigated in this study are relatively specific to OCD. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.b.32407","type":"journal-article","created":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T06:12:41Z","timestamp":1448863961000},"page":"325-332","source":"Crossref","is-referenced-by-count":53,"title":["Disorder\u2010specific genetic factors in obsessive\u2010compulsive disorder: A comprehensive meta\u2010analysis"],"prefix":"10.1002","volume":"171","author":[{"given":"Steven","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of British Columbia Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/med:psych\/9780195310641.003.0013"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association.2013. Diagnostic and statistical manual of mental disorders 5th ed. Arlington VA: Author.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.06.006"},{"key":"e_1_2_5_5_1","unstructured":"BorensteinM HedgesLV HigginsJ RothsteinH.2009a. Comprehensive Meta\u2010analysis (Version 2.2050). [Computer program.] Englewood NJ: Biostat."},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470743386"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.110.1.49"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32077"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-006-9076-5"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30494"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2014.09.014"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-009-0694-x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.3.469"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23180"},{"key":"e_1_2_5_16_1","first-page":"669","article-title":"Genetic association of obsessive\u2010compulsive disorder and serotonin transporter gene polymorphisms: A meta\u2010analysis of data from case\u2010control studies","volume":"26","author":"He XY","year":"2012","journal-title":"Chinese Mental Health J"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/503850"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.120178"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005415823867"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsp052"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpp.693"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2009.36"},{"key":"e_1_2_5_23_1","first-page":"181","article-title":"An integrated meta\u2010analysis of the association between 5\u2010HTTLPR and autism spectrum disorder","volume":"42","author":"Mo S","year":"2013","journal-title":"Acta Medicinae Universitatis Scientiae et Technologiae Huazhong"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780195367294.001.0001"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001664"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2009.02.019"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7139.1236"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001951"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199001000-00010"},{"key":"e_1_2_5_31_1","first-page":"313","article-title":"Update on the reliability of diagnosis in older psychiatric outpatients using the structured clinical interview for DSM\u2010III\u2010R","volume":"1","author":"Segal DL","year":"1995","journal-title":"J Clin Geropsychol"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1991.tb03123.x"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.09.028"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32137"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-013-8516-5"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32248"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0021403"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2011.09.008"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.76"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)62413-0"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820080038006"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1053\/comp.2001.24556"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-014-1970-7"},{"key":"e_1_2_5_44_1","first-page":"202","article-title":"Meta analysis on the relationship between 5\u2010hydroxytryptamine 2A receptor gene polymorphism T102C and depression","volume":"39","author":"Zhou C","year":"2014","journal-title":"J Chongqing Medical University"}],"container-title":["American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.b.32407","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.b.32407","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.32407","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajmg.b.32407","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.32407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T02:32:17Z","timestamp":1696559537000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.b.32407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,30]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1002\/ajmg.b.32407"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.b.32407","archive":["Portico"],"relation":{},"ISSN":["1552-4841","1552-485X"],"issn-type":[{"value":"1552-4841","type":"print"},{"value":"1552-485X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,30]]}}}