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Several genetic linkage analyses and genome wide association studies identified <jats:italic>NRG1<\/jats:italic> as a susceptibility gene of schizophrenia, which was validated by its role in neurodevelopment, glutamate, and other neurotransmitter receptor expression regulation. To further investigate whether <jats:italic>NRG1<\/jats:italic> is a shared risk gene for major depressive disorder, bipolar disorder as well as schizophrenia, we performed an association study among 1,248 schizophrenia cases, 1,056 major depression cases, 1,344 bipolar disorder cases, and 1,248 controls. Totally 15 tag SNPs were genotyped and analyzed, and no population stratification was found in our sample set. Among the sites, rs4236710 (corrected <jats:italic>P<\/jats:italic><jats:sub>genotye\u2009<\/jats:sub>=\u20090.015) and rs4512342 (<jats:italic>P<\/jats:italic><jats:sub>allele\u2009<\/jats:sub>=\u20090.03, <jats:italic>P<\/jats:italic><jats:sub>genotye\u2009<\/jats:sub>=\u20090.045 after correction) were associated with schizophrenia, and rs2919375 (corrected <jats:italic>P<\/jats:italic><jats:sub>genotye\u2009<\/jats:sub>=\u20090.004) was associated with major depressive disorder. The haplotype rs4512342\u2010rs6982890 showed association with schizophrenia (<jats:italic>P\u2009<\/jats:italic>=\u20090.03 for haplotype \u201cTC\u201d after correction), and haplotype rs4531002\u2010rs11989919 proved to be a shared risk factor for both major depressive disorder (\u201cCC\u201d: corrected <jats:italic>P\u2009<\/jats:italic>=\u20090.009) and bipolar disorder (\u201cCT\u201d: corrected <jats:italic>P\u2009<\/jats:italic>=\u20090.003). Our results confirmed that <jats:italic>NRG1<\/jats:italic> was a shared common susceptibility gene for major mental disorders in Han Chinese population. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.b.32428","type":"journal-article","created":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T20:10:02Z","timestamp":1455826202000},"page":"468-478","source":"Crossref","is-referenced-by-count":26,"title":["Genetic association between <i>NRG1<\/i> and schizophrenia, major depressive disorder, bipolar disorder in Han Chinese population"],"prefix":"10.1002","volume":"171","author":[{"given":"Zujia","family":"Wen","sequence":"first","affiliation":[{"name":"Bio\u2010X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science Shanghai Jiao Tong University Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Chen","sequence":"additional","affiliation":[{"name":"Bio\u2010X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science Shanghai Jiao Tong University Shanghai P.R. China"},{"name":"Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raja Amjad Waheed","family":"Khan","sequence":"additional","affiliation":[{"name":"Bio\u2010X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science Shanghai Jiao Tong University Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijian","family":"Song","sequence":"additional","affiliation":[{"name":"Bio\u2010X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science Shanghai Jiao Tong University Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"Bio\u2010X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science Shanghai Jiao Tong University Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Li","sequence":"additional","affiliation":[{"name":"Bio\u2010X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science Shanghai Jiao Tong University Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawei","family":"Shen","sequence":"additional","affiliation":[{"name":"Bio\u2010X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science Shanghai Jiao Tong University Shanghai P.R. 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