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With an estimated heritability of about 40%, genetics is important in its development. We performed an exploratory genome\u2010wide association (GWA) analysis of childhood aggressiveness in attention deficit hyperactivity disorder (ADHD) to gain insight into the underlying biological processes associated with this trait. Our primary sample consisted of 1,060 adult ADHD patients (aADHD). To further explore the genetic architecture of childhood aggressiveness, we performed enrichment analyses of suggestive genome\u2010wide associations observed in aADHD among GWA signals of dimensions of oppositionality (defiant\/vindictive and irritable dimensions) in childhood ADHD (cADHD). No single polymorphism reached genome\u2010wide significance (<jats:italic>P<\/jats:italic>\u2009&lt;\u20095.00E\u201008). The strongest signal in aADHD was observed at rs10826548, within a long noncoding RNA gene (beta\u2009=\u2009\u22121.66, standard error (SE)\u2009=\u20090.34, <jats:italic>P\u2009<\/jats:italic>=\u20091.07E\u201006), closely followed by rs35974940 in the neurotrimin gene (beta\u2009=\u20093.23, SE\u2009=\u20090.67, <jats:italic>P<\/jats:italic>\u2009=\u20091.26E\u201006). The top GWA SNPs observed in aADHD showed significant enrichment of signals from both the defiant\/vindictive dimension (Fisher's <jats:italic>P<\/jats:italic>\u2010value\u2009=\u20092.28E\u201006) and the irritable dimension in cADHD (Fisher's <jats:italic>P<\/jats:italic>\u2010value\u2009=\u20090.0061). In sum, our results identify a number of biologically interesting markers possibly underlying childhood aggressiveness and provide targets for further genetic exploration of aggressiveness across psychiatric disorders. \u00a9 2016 The Authors. <jats:italic>American Journal of Medical Genetics Part B: Neuropsychiatric Genetics<\/jats:italic> Published by Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.b.32434","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T01:43:34Z","timestamp":1459302214000},"page":"733-747","source":"Crossref","is-referenced-by-count":44,"title":["Genome\u2010wide analyses of aggressiveness in attention\u2010deficit hyperactivity disorder"],"prefix":"10.1002","volume":"171","author":[{"given":"Erlend J.","family":"Brevik","sequence":"first","affiliation":[{"name":"Division of Psychiatry Haukeland University Hospital Bergen Norway"},{"name":"K.G. 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