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This study documents that the 15q13.3 deletion and duplication exhibit pathogenicity for COS, with both copy number variants (CNVs) sharing a disrupted CHRNA7 gene. CHRNA7 encodes the neuronal alpha7 nicotinic acetylcholine receptor (\u03b17nAChR) and is a candidate gene that has been suggested as a pathophysiological process mediating adult\u2010onset schizophrenia (AOS) and other neurodevelopmental disorders. These results support the incomplete penetrance and variable expressivity of this CNV and represent the first report of 15q13.3 duplication carriers exhibiting COS. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. <jats:italic>American Journal of Medical Genetics Part B: Neuropsychiatric Genetics<\/jats:italic> published by Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.b.32439","type":"journal-article","created":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T07:16:31Z","timestamp":1457766991000},"page":"777-783","source":"Crossref","is-referenced-by-count":32,"title":["15q13.3 duplication in two patients with childhood\u2010onset schizophrenia"],"prefix":"10.1002","volume":"171","author":[{"given":"Dale","family":"Zhou","sequence":"first","affiliation":[{"name":"Child Psychiatry Branch National Institute of Mental Health NIH Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Gochman","sequence":"additional","affiliation":[{"name":"Child Psychiatry Branch National Institute of Mental Health NIH Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane D.","family":"Broadnax","sequence":"additional","affiliation":[{"name":"Child Psychiatry Branch National Institute of Mental Health NIH Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith L.","family":"Rapoport","sequence":"additional","affiliation":[{"name":"Child Psychiatry Branch National Institute of Mental Health NIH Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwangmi","family":"Ahn","sequence":"additional","affiliation":[{"name":"Child Psychiatry Branch National Institute of Mental Health NIH Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-009-0024-y"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.59"},{"key":"e_1_2_5_4_1","unstructured":"American Psychiatric Association.2000. 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