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This study compared gene expression profiles from a genetic mouse model of aggression with zebrafish, an animal model traditionally used to study aggression. A meta\u2010analytic, cross\u2010species approach was used to identify genomic variants associated with aggressive behavior. The Rankprod algorithm was used to evaluated mRNA differences from prefrontal cortex tissues of three sets of mouse lines (N\u2009=\u200918) selectively bred for low and high aggressive behavior (SAL\/LAL, TA\/TNA, and NC900\/NC100). The same approach was used to evaluate mRNA differences in zebrafish (N\u2009=\u200912) exposed to aggressive or non\u2010aggressive social encounters. Results were compared to uncover genes consistently implicated in aggression across both studies. Seventy\u2010six genes were differentially expressed (PFP\u2009&lt;\u20090.05) in aggressive compared to non\u2010aggressive mice. Seventy genes were differentially expressed in zebrafish exposed to a fight encounter compared to isolated zebrafish. Seven genes (<jats:italic>Fos<\/jats:italic>, <jats:italic>Dusp1<\/jats:italic>, <jats:italic>Hdac4<\/jats:italic>, <jats:italic>Ier2<\/jats:italic>, <jats:italic>Bdnf<\/jats:italic>, <jats:italic>Btg2<\/jats:italic>, and <jats:italic>Nr4a1<\/jats:italic>) were differentially expressed across both species 5 of which belonging to a gene\u2010network centred on the <jats:italic>c\u2010Fos<\/jats:italic> gene hub. Network analysis revealed an association with the MAPK signaling cascade. In human studies <jats:italic>HDAC4<\/jats:italic> haploinsufficiency is a key genetic mechanism associated with brachydactyly mental retardation syndrome (BDMR), which is associated with aggressive behaviors. Moreover, the HDAC4 receptor is a drug target for valproic acid, which is being employed as an effective pharmacological treatment for aggressive behavior in geriatric, psychiatric, and brain\u2010injury patients. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.b.32451","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T11:59:03Z","timestamp":1461067143000},"page":"827-838","source":"Crossref","is-referenced-by-count":43,"title":["Transcriptome analysis of genes and gene networks involved in aggressive behavior in mouse and zebrafish"],"prefix":"10.1002","volume":"171","author":[{"given":"Karim","family":"Malki","sequence":"first","affiliation":[{"name":"King's College London Social, Genetic and Developmental Psychiatry Centre (MRC), Institute of Psychiatry, Psychology and Neuroscience United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebba","family":"Du 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