{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:40:14Z","timestamp":1780072814750,"version":"3.54.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001734","name":"University of Copenhagen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000329","name":"Novo Nordisk UK Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:label\/><jats:p>Huntington's disease (HD) is associated with risk for developing psychiatric symptoms. Vulnerability or resilience to psychiatric symptoms may be associated with personality traits. This exploratory study, aimed to investigate personality traits in a large cohort of HD carriers and at risk gene\u2010expansion negative individuals (HD non\u2010carriers), exploring whether carrying the HD gene or growing up in an HD family influences personality traits. Forty\u2010seven HD carriers, Thirty\u2010nine HD non\u2010carriers, and 121 healthy controls answered the Danish version of the revised NEO personality inventory. Comparisons between HD carriers and HD non\u2010carriers were mostly non\u2010significant but the combined group of HD carriers and non\u2010carriers showed significantly higher scores on the facets: \u201chostility,\u201d \u201cassertiveness,\u201d and \u201cactivity\u201d and on the trait \u201cConscientiousness\u201d relative to controls, \u201cConscientiousness\u201d have been associated with resilience to psychiatric symptoms. Twelve HD carriers and non\u2010carriers were classified as depressed and showed significantly lower scores on \u201cExtraversion\u201d and \u201cConscientiousness\u201d and significantly higher scores on \u201cNeuroticism,\u201d which are associated with vulnerability to psychiatric symptoms. Our findings suggest that, there is no direct effect of the HD gene on personality traits, but that personality assessment may be relevant to use when identifying individuals from HD families who are vulnerable to develop psychiatric symptoms. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.b.32501","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T02:49:43Z","timestamp":1476326983000},"page":"1153-1160","source":"Crossref","is-referenced-by-count":7,"title":["Personality traits in Huntington's disease: An exploratory study of gene expansion carriers and non\u2010carriers"],"prefix":"10.1002","volume":"171","author":[{"given":"Ida Unmack","family":"Larsen","sequence":"first","affiliation":[{"name":"Neurogenetics Clinic, Danish Dementia Research Center, Department of Neurology, Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"Department of Psychology University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik Lykke","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Department of Public Health and Center for Healthy Aging University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tua","family":"Vinther\u2010Jensen","sequence":"additional","affiliation":[{"name":"Neurogenetics Clinic, Danish Dementia Research Center, Department of Neurology, Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"Department of Cellular and Molecular Medicine, Section of Neurogenetics University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen Erik","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Neurogenetics Clinic, Danish Dementia Research Center, Department of Neurology, Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"Department of Cellular and Molecular Medicine, Section of Neurogenetics University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitte Moos","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging Rigshospitalet Copenhagen Denmark"},{"name":"Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmus","family":"Vogel","sequence":"additional","affiliation":[{"name":"Neurogenetics Clinic, Danish Dementia Research Center, Department of Neurology, Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"Department of Psychology University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(94)90006-X"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2014.01.010"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2002.0o456.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2005.05.001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780199929146.003.0003"},{"key":"e_1_2_8_7_1","first-page":"1","article-title":"Predictive testing for Huntington's disease: Risk perception, reasons for testing and psychological profile of test applicants","volume":"6","author":"Decruyenaere M","year":"1995","journal-title":"Genet Couns"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.11.034"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.38.12.852"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2012.07.004"},{"key":"e_1_2_8_11_1","first-page":"1028","article-title":"Interaction without intent: The shape of the social world in Huntington's disease","volume":"10","author":"Eddy CM","year":"2015","journal-title":"Soc Coqn Affect Neurosci"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000190"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291707000244"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2006.00702.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870100211"},{"key":"e_1_2_8_16_1","volume-title":"NEO\u2010PI\u2010R manual\u2014Clinical. Danish version","author":"Hansen HS","year":"2004"},{"key":"e_1_2_8_17_1","first-page":"3","volume-title":"Huntington's disease","author":"Harper PS","year":"2014"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110204"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.103309"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.10.1113"},{"issue":"3","key":"e_1_2_8_21_1","first-page":"192","article-title":"Longitudinal personality changes among presymptomatic Huntington disease gene carriers","volume":"15","author":"Kirkwood SC","year":"2002","journal-title":"Neuropsychiatry Neuropsychol Behav Neurol"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.04.025"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000224"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.12.005"},{"issue":"3","key":"e_1_2_8_25_1","first-page":"1","article-title":"I'm scared of being like mum: The experience of adolescents living in families with huntington disease","volume":"4","author":"Mand CM","year":"2015","journal-title":"J Huntingtons Dis"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511812743"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467-6494.694154"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329170400412X"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa5703_3"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-6916.2007.00047.x"},{"issue":"11","key":"e_1_2_8_31_1","first-page":"393","article-title":"Huntington's chorea in relation to the heredity of personality disorders","volume":"66","author":"Schiele BC","year":"1946","journal-title":"J Lancet"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.166"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617715000090"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2005.11.019"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2011.01778.x"},{"issue":"4","key":"e_1_2_8_37_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1176\/jnp.2007.19.4.441","article-title":"Psychopathology in verified Huntington's disease gene carriers","volume":"19","author":"van Duijn E","year":"2007","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.12.016"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-014-0114-8"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12628"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13m08855"}],"container-title":["American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.b.32501","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.b.32501","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.32501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T23:12:46Z","timestamp":1696633966000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.b.32501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,7]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1002\/ajmg.b.32501"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.b.32501","archive":["Portico"],"relation":{},"ISSN":["1552-4841","1552-485X"],"issn-type":[{"value":"1552-4841","type":"print"},{"value":"1552-485X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,7]]}}}