{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:45:12Z","timestamp":1784022312402,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T00:00:00Z","timestamp":1490659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"None"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:label\/><jats:p>Depression and anxiety are apparent symptoms in the early onset or acute phase of schizophrenia (SZ), which complicate timely diagnosis and treatment. It is imperative to seek an indicator to distinguish schizophrenia from depressive and anxiety disorders. Using lncRNA microarray profiling and RT\u2010PCR, three up\u2010regulated lncRNAs in SZ, six down\u2010regulated lncRNAs in major depressive disorder (MDD), and three up\u2010regulated lncRNAs in generalized anxiety disorder (GAD) had been identified as potential biomarkers. All the lncRNAs were, then, cross\u2010validated in 40 SZ patients, 40 MDD patients, 40 GAD patients, and 40 normal controls. Compared with controls, three up\u2010regulated SZ lncRNAs had a significantly down\u2010regulated expression in GAD, and no remarkable differences existed between MDD and the controls. Additionally, the six down\u2010regulated MDD lncRNAs were expressed in an opposite fashion in SZ, and the expression of the three up\u2010regulated GAD lncRNAs were significantly different between SZ and GAD. These results indicate that the expression patterns of the three up\u2010regulated SZ lncRNAs could not be completely replicated in MDD and GAD, and vice versa. Thus, these three SZ lncRNAs seem to be established as potential indicators for diagnosis of schizophrenia and distinguishing it from MDD and GAD. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.b.32521","type":"journal-article","created":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T16:25:07Z","timestamp":1490718307000},"page":"335-341","source":"Crossref","is-referenced-by-count":18,"title":["Can lncRNAs be indicators for the diagnosis of early onset or acute schizophrenia and distinguish major depressive disorder and generalized anxiety disorder?\u2014A cross validation analysis"],"prefix":"10.1002","volume":"174","author":[{"given":"Xuelian","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Health Care Changzhou Maternal and Child Health Care Hospital Affiliated With Nanjing Medical University Changzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation No. 102 Hospital of the Chinese People's Liberation Army Changzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingming","family":"Kong","sequence":"additional","affiliation":[{"name":"Prevention and Treatment Center for Psychological Diseases No. 102 Hospital of the Chinese People's Liberation Army Changzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjun","family":"He","sequence":"additional","affiliation":[{"name":"Prevention and Treatment Center for Psychological Diseases No. 102 Hospital of the Chinese People's Liberation Army Changzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunhong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Prevention and Treatment Center for Psychological Diseases No. 102 Hospital of the Chinese People's Liberation Army Changzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengdong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology No. 102 Hospital of the Chinese People's Liberation Army Changzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aifang","family":"Zhong","sequence":"additional","affiliation":[{"name":"Clinical Laboratory No. 102 Hospital of the Chinese People's Liberation Army Changzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanshuai","family":"Li","sequence":"additional","affiliation":[{"name":"Gopath Diagnostic Laboratory Co. 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