{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:47:01Z","timestamp":1791283621799,"version":"4.1.0"},"reference-count":87,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T00:00:00Z","timestamp":1497312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:italic>Catechol\u2010O\u2010methyltransferase (COMT) Val158Met<\/jats:italic>\n                      is widely regarded as potentially important for understanding the genetic etiology of many different psychiatric disorders. The present study appears to be the first comprehensive meta\u2010analysis of\n                      <jats:italic>COMT<\/jats:italic>\n                      genetic association studies to cover all psychiatric disorders for which there were available data, published in any language, and with an emphasis on investigating disorder subtypes (defined clinically or by demographic or other variables). Studies were included if they reported one or more datasets (i.e., some studies examined more than one clinical group) in which there were sufficient information to compute effect sizes. A total of 363 datasets were included, consisting of 56,998 cases and 74,668 healthy controls from case control studies, and 2,547 trios from family based studies. Fifteen disorders were included. Attention\u2010deficit hyperactivity disorder and panic disorder were associated with the Val allele for Caucasian samples. Substance\u2010use disorder, defined by DSM\u2010IV criteria, was associated with the Val allele for Asian samples. Bipolar disorder was associated with the Met allele in Asian samples. Obsessive\u2010compulsive disorder tended to be associated with the Met allele only for males. There was suggestive evidence that the Met allele is associated with an earlier age of onset of schizophrenia. Results suggest pleiotropy and underscore the importance of examining subgroups\u2014defined by variables such as age of onset, sex, ethnicity, and diagnostic system\u2014rather than examining disorders as monolithic constructs.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajmg.b.32556","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T08:12:40Z","timestamp":1497341560000},"page":"199-210","source":"Crossref","is-referenced-by-count":66,"title":["Association between\n                    <i>COMT Val158Met<\/i>\n                    and psychiatric disorders: A comprehensive meta\u2010analysis"],"prefix":"10.1002","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6314-6080","authenticated-orcid":false,"given":"Steven","family":"Taylor","sequence":"first","affiliation":[{"name":"University of British Columbia British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60240-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-06-02008.2003"},{"key":"e_1_2_6_4_1","volume-title":"Diagnostic and statistical manual of mental disorders","year":"2013"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.06.006"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12131"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S0021-9258(18)64731-3","article-title":"Enzymatic O\u2010methylation of epinephrine and other catechols","volume":"233","author":"Axelrod J.","year":"1958","journal-title":"The Journal of Biological Chemistry"},{"key":"e_1_2_6_8_1","article-title":"Meta\u2010analysis of family\u2010based and case\u2010control genetic association studies that use the same cases","author":"Bagos P. 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