{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:50:07Z","timestamp":1791298207946,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T00:00:00Z","timestamp":1536796800000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T00:00:00Z","timestamp":1505260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["U01MH087981"],"award-info":[{"award-number":["U01MH087981"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["HU0001\u201015\u20102\u20100004"],"award-info":[{"award-number":["HU0001\u201015\u20102\u20100004"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:label\/><jats:p>Suicide is a global public health problem with particular resonance for the US military. Genetic risk factors for suicidality are of interest as indicators of susceptibility and potential targets for intervention. We utilized population\u2010based nonclinical cohorts of US military personnel (discovery: <jats:italic>N<\/jats:italic>\u2009=\u2009473 cases and <jats:italic>N<\/jats:italic>\u2009=\u20099778 control subjects; replication: <jats:italic>N\u2009<\/jats:italic>=\u2009135 cases and <jats:italic>N<\/jats:italic>\u2009=\u20096879 control subjects) and a clinical case\u2010control sample of recent suicide attempters (<jats:italic>N\u2009<\/jats:italic>=\u200951 cases and <jats:italic>N<\/jats:italic>\u2009=\u2009112 control subjects) to conduct GWAS of suicide attempts (SA). Genomewide association was evaluated within each ancestral group (European\u2010, African\u2010, Latino\u2010American) and study using logistic regression models. Meta\u2010analysis of the European ancestry discovery samples revealed a genomewide significant locus in association with SA near <jats:italic>MRAP2<\/jats:italic> (melanocortin 2 receptor accessory protein 2) and <jats:italic>CEP162<\/jats:italic> (centrosomal protein 162); 12 genomewide significant SNPs in the region; peak SNP rs12524136\u2010T, OR\u2009=\u20092.88, <jats:italic>p<\/jats:italic>\u2009=\u20095.24E\u201010. These findings were not replicated in the European ancestry subsamples of the replication or suicide attempters samples. However, the association of the peak SNP remained significant in a meta\u2010analysis of all studies and ancestral subgroups (OR\u2009=\u20092.18, 95%CI 1.70, 2.80). Polygenic risk score (PRS) analyses showed some association of SA with bipolar disorder. The association with SNPs encompassing <jats:italic>MRAP2<\/jats:italic>, a gene expressed in brain and adrenal cortex and involved in neural control of energy homeostasis, points to this locus as a plausible susceptibility gene for suicidality that should be further studied. Larger sample sizes will be needed to confirm and extend these findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.b.32594","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T13:26:40Z","timestamp":1505309200000},"page":"786-797","source":"Crossref","is-referenced-by-count":59,"title":["Genomewide association studies of suicide attempts in US soldiers"],"prefix":"10.1002","volume":"174","author":[{"given":"Murray B.","family":"Stein","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of California San Diego and VA San Diego Healthcare System La Jolla California"},{"name":"Department of Family Medicine and Public Health University of California San Diego La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin B.","family":"Ware","sequence":"additional","affiliation":[{"name":"Institute for Social Research University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colter","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Institute for Social Research University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Yen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital Harvard Medical School Boston Massachusetts"},{"name":"Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine Massachusetts General Hospital Boston Massachusetts"},{"name":"Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Cambridge Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Borja","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxi","family":"Cai","sequence":"additional","affiliation":[{"name":"Harvard T.H. Chan School of Public Health Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine L.","family":"Dempsey","sequence":"additional","affiliation":[{"name":"Uniformed Services University of the Health Sciences Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol S.","family":"Fullerton","sequence":"additional","affiliation":[{"name":"Uniformed Services University of the Health Sciences Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Gelernter","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry, Genetics, and Neurobiology Yale University New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G.","family":"Heeringa","sequence":"additional","affiliation":[{"name":"Institute for Social Research University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Public Health University of California San Diego La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C.","family":"Kessler","sequence":"additional","affiliation":[{"name":"Department of Health Care Policy Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Naifeh","sequence":"additional","affiliation":[{"name":"Uniformed Services University of the Health Sciences Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew K.","family":"Nock","sequence":"additional","affiliation":[{"name":"Department of Psychology Harvard University Cambridge Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Ripke","sequence":"additional","affiliation":[{"name":"Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Cambridge Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Public Health University of California San Diego La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean C.","family":"Beckham","sequence":"additional","affiliation":[{"name":"Durham Veterans Affairs Health Care System and Duke University Health System Durham North Carolina"},{"name":"VA MIRECC Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan A.","family":"Kimbrel","sequence":"additional","affiliation":[{"name":"Durham Veterans Affairs Health Care System and Duke University Health System Durham North Carolina"},{"name":"VA MIRECC Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"VA Mid\u2010Atlantic Mental Illness Research, Education, and Clinical Center (MIRECC) Workgroup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"Ursano","sequence":"additional","affiliation":[{"name":"Uniformed Services University of the Health Sciences Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan W.","family":"Smoller","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital Harvard Medical School Boston Massachusetts"},{"name":"Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine Massachusetts General Hospital Boston Massachusetts"},{"name":"Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Cambridge Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.2732"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/M15-2785"},{"key":"e_1_2_7_4_1","unstructured":"Armed Forces Health Surveillance Center. (2014). Surveillance snapshot: Manner and cause of death active component U.S. Armed Forces 1998\u20132013. p21."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1233000"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.03.049"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809918106"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13742-015-0047-8"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2711"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004219"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-15-0292"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.92420"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32330"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.08.005"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.50"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.14010008"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3250"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00213"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.105"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.65164"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209215"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.257"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2016.00158"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32247"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2010.06.008"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.180"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.112"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1521\/psyc.2013.76.2.97"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.30"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-12-0501"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2016.1478"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.14020194"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.10040541"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2010.70"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.10111704"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.943"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.03.016"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.21"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13595"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020690"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2014.08.006"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.187"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2016.0350"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-017-0781-y"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291711000833"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3839"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1521\/psyc.2013.76.2.95"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1521\/psyc.2014.77.2.107"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.0987"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2739"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61611-6"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.4"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32423"}],"container-title":["American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.b.32594","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.32594","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajmg.b.32594","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/ajmg.b.32594","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.32594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T16:57:23Z","timestamp":1696611443000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.b.32594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,13]]},"references-count":52,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/ajmg.b.32594"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.b.32594","archive":["Portico"],"relation":{},"ISSN":["1552-4841","1552-485X"],"issn-type":[{"value":"1552-4841","type":"print"},{"value":"1552-485X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,13]]}}}