{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:35:09Z","timestamp":1791984909317,"version":"4.4.0"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T00:00:00Z","timestamp":1510617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Guangzhou Municipal Key Discipline in Medicine for Guangzhou Brain Hospital","award":["GBH2014-ZD08"],"award-info":[{"award-number":["GBH2014-ZD08"]}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"crossref","award":["2013B021800074"],"award-info":[{"award-number":["2013B021800074"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81261120415"],"award-info":[{"award-number":["81261120415"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["91332205"],"award-info":[{"award-number":["91332205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81130024"],"award-info":[{"award-number":["81130024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["973 Program 2007CB512301"],"award-info":[{"award-number":["973 Program 2007CB512301"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Alberta Centennial Addiction and Mental Health Research Chair"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>In this study, we investigated the association between bipolar I disorder (BDI) and between cognitive deficits therein and SNPs in GABAergic receptor genes. The sample comprised 477 patients with BDI and 438 healthy controls, with three neurocognitive tests being administered in 123 patients and 164 controls. For three SNPs, rs505474, rs1398175, and rs4868029 in the <jats:italic>GABRA2<\/jats:italic>, <jats:italic>GABRA4<\/jats:italic>, and <jats:italic>GABRP<\/jats:italic> genes, respectively, their allele frequencies were significantly different between patients and controls (Bonferroni\u2010adjusted <jats:italic>p<\/jats:italic>\u2009=\u2009values 3.84\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup>, 9.92\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup>, and 1.22\u2009\u00d7\u200910<jats:sup>\u22122<\/jats:sup>, respectively). Four haplotypes were significantly associated with BDI (TA and AG for rs3815762 and rs4868029 in <jats:italic>GABRP<\/jats:italic>, GG for rs11636988 and rs8024256 in <jats:italic>GABRB3<\/jats:italic> and GAGG for rs2197414, rs4921195, rs13188991, and rs11956731 in <jats:italic>GABRA6<\/jats:italic>, with <jats:italic>p<\/jats:italic> values of 0.0038, 0.044, 0.0176, and 0.0267, respectively, on 10,000 permutations). Furthermore, the SNP (rs2912585) within 250\u2009kb upstream of the <jats:italic>GABRB3<\/jats:italic> gene displayed a strong association with the Tower of Hanoi (TOH) executive time in the patient group (<jats:italic>p<\/jats:italic>\u2009=\u20092.844\u2009\u00d7\u200910<jats:sup>\u22126<\/jats:sup>). One other SNP (rs754661), which is located at the intronic region of the same gene, was associated with the global trait of the executive function and post hoc analysis showed significant SNP by group effect (<jats:italic>p<\/jats:italic>\u2009=\u20090.0094). Our study supports previous findings that GABA<jats:sub>A<\/jats:sub> receptor genes are associated with bipolar disorder; it also suggests that the GABA<jats:sub>A<\/jats:sub> genes, especially the <jats:italic>GABRB3<\/jats:italic> gene, might play a role in the executive function deficit in bipolar disorder, although future replication with a larger sample size is needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.b.32601","type":"journal-article","created":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T13:16:43Z","timestamp":1510665403000},"page":"50-67","source":"Crossref","is-referenced-by-count":6,"title":["Contribution of genes in the GABAergic pathway to bipolar disorder and its executive function deficit in the Chinese Han population"],"prefix":"10.1002","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8175-0625","authenticated-orcid":false,"given":"Hongyan","family":"Ren","sequence":"first","affiliation":[{"name":"Affiliated Brain Hospital of Guangzhou Medical University Guangzhou Brain Hospital Guangzhou Guangdong P.R. China"},{"name":"Psychiatric Laboratory and Mental Health Center State Key Laboratory of Biotherapy, West China Hospital, Sichuan University Chengdu Sichuan P.R. China"},{"name":"Psychiatry and Medical Genetics University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Guan","sequence":"additional","affiliation":[{"name":"Affiliated Brain Hospital of Guangzhou Medical University Guangzhou Brain Hospital Guangzhou Guangdong P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liansheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Psychiatric Laboratory and Mental Health Center State Key Laboratory of Biotherapy, West China Hospital, Sichuan University Chengdu Sichuan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Lin","sequence":"additional","affiliation":[{"name":"Affiliated Brain Hospital of Guangzhou Medical University Guangzhou Brain Hospital Guangzhou Guangdong P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yincheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Psychiatric Laboratory and Mental Health Center State Key Laboratory of Biotherapy, West China Hospital, Sichuan University Chengdu Sichuan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenxing","family":"Yang","sequence":"additional","affiliation":[{"name":"Psychiatric Laboratory and Mental Health Center State Key Laboratory of Biotherapy, West China Hospital, Sichuan University Chengdu Sichuan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Li","sequence":"additional","affiliation":[{"name":"Affiliated Brain Hospital of Guangzhou Medical University Guangzhou Brain Hospital Guangzhou Guangdong P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Ma","sequence":"additional","affiliation":[{"name":"Psychiatric Laboratory and Mental Health Center State Key Laboratory of Biotherapy, West China Hospital, Sichuan University Chengdu Sichuan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongchao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Affiliated Brain Hospital of Guangzhou Medical University Guangzhou Brain Hospital Guangzhou Guangdong P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Deng","sequence":"additional","affiliation":[{"name":"Affiliated Brain Hospital of Guangzhou Medical University Guangzhou Brain Hospital Guangzhou Guangdong P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine J.","family":"Aitchison","sequence":"additional","affiliation":[{"name":"Psychiatry and Medical Genetics University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Cao","sequence":"additional","affiliation":[{"name":"Affiliated Brain Hospital of Guangzhou Medical University Guangzhou Brain Hospital Guangzhou Guangdong P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Psychiatric Laboratory and Mental Health Center State Key Laboratory of Biotherapy, West China Hospital, Sichuan University Chengdu Sichuan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1424958112"},{"issue":"1","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/2194-7511-1-12","article-title":"Bipolar disorders in DSM\u20105: Strengths, problems and perspectives","volume":"1","author":"Angst J.","year":"2013","journal-title":"International Journal of Bipolar Disorders"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1076\/1380-3395(200008)22:4;1-0;FT518"},{"issue":"02","key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1017\/S0140525X06239037","article-title":"He terogeneity in fluid cognition and some neural underpinnings","volume":"29","author":"Benga O.","year":"2006","journal-title":"Behavioral and Brain Sciences"},{"issue":"1","key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jad.2009.05.014","article-title":"Clinical and neurocognitive predictors of functional outcome in bipolar euthymic patients: A long\u2010term, follow\u2010up study","volume":"121","author":"Bonnin C.","year":"2010","journal-title":"Journal of Affective Disorders"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2016.04.002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2001.030207.x"},{"issue":"1","key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.schres.2016.01.008","article-title":"Deficits in GABA A receptor function and working memory in non\u2010smokers with schizophrenia","volume":"171","author":"Bridgman A. C.","year":"2016","journal-title":"Schizophrenia Research"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05911"},{"issue":"194","key":"e_1_2_8_11_1","article-title":"Executive function is selectively impaired in old age bipolar depression","volume":"8","author":"Caixeta L.","year":"2017","journal-title":"Frontiers in Psychology"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(90)90144-S"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.10.1980"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1262110"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00487.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.66"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2009.00110.x"},{"issue":"6","key":"e_1_2_8_19_1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1001\/jamapsychiatry.2014.157","article-title":"Differential effects of common variants in SCN2A on general cognitive ability, brain physiology, and messenger RNA expression in schizophrenia cases and control individuals","volume":"71","author":"Dickinson D.","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"e_1_2_8_20_1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jad.2017.04.010","article-title":"Executive functioning deficits among adults with Bipolar Disorder (types I and II): A systematic review and meta\u2010analysis","volume":"218","author":"Dickinson T.","year":"2017","journal-title":"Journal of Affective Disorders"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000119108"},{"issue":"4","key":"e_1_2_8_22_1","first-page":"353","article-title":"Association and linkage studies of candidate genes involved in GABAergic neurotransmission in lithium\u2010responsive bipolar disorder","volume":"25","author":"Duffy A.","year":"2000","journal-title":"Journal of Psychiatry and Neuroscience"},{"issue":"1","key":"e_1_2_8_23_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.schres.2010.12.025","article-title":"Deficits in GABA B receptor system in schizophrenia and mood disorders: A postmortem study","volume":"128","author":"Fatemi S. H.","year":"2011","journal-title":"Schizophrenia Research"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2004.00113.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15516709cog2502_4"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201587"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.617"},{"issue":"5","key":"e_1_2_8_28_1","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1093\/nar\/gkt1249","article-title":"Systematic discovery and characterization of regulatory motifs in ENCODE TF binding experiments","volume":"42","author":"Kheradpour P.","year":"2013","journal-title":"Nucleic Acids Research"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.99"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2014.00003"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2012.12.018"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08m04663yel"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60072-6"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2012.12.018"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.032"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4734-03.2004"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07450-0"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2009.03.005"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1354"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.2.286"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001739"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(95)00025-I"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00442-5"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/19.1.149"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.2466\/pms.1958.8.3.271"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/518314a"},{"issue":"40","key":"e_1_2_8_47_1","doi-asserted-by":"crossref","first-page":"41422","DOI":"10.1074\/jbc.M401354200","article-title":"Analysis of the set of GABAA receptor genes in the human genome","volume":"279","author":"Simon J.","year":"2004","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001418"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5408.1657"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003235"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.10.009"},{"key":"e_1_2_8_52_1","unstructured":"Weisstein E. W.(2003). Tower of Hanoi. Retrieved fromhttp:\/\/mathworld.wolfram.com\/TowerofHanoi.html"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-013-1380-5"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2014.07.015"},{"issue":"2","key":"e_1_2_8_55_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF02294531","article-title":"On the relationship between the higher\u2010order factor model and the hierarchical factor model","volume":"64","author":"Yung Y.\u2010F.","year":"1999","journal-title":"Psychometrika"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.08.039"}],"container-title":["American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.b.32601","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.32601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T16:28:01Z","timestamp":1696004881000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.b.32601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,14]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/ajmg.b.32601"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.b.32601","archive":["Portico"],"relation":{},"ISSN":["1552-4841","1552-485X"],"issn-type":[{"value":"1552-4841","type":"print"},{"value":"1552-485X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,14]]}}}