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The inconsistency may reflect a combination of clinical and methodological variability, which leads to limited reproducibility of these findings. The samples included 59 patients with MDD and 31 controls from Sample 1, 29 patients with MDD and 24 controls from Sample 2, and 31 patients with schizophrenia and 37 controls from Sample 3. Global\u2010brain FC (GFC) and an overlapping technique were applied to analyze the imaging data. Compared with healthy controls, patients with MDD in Samples 1 and 2 showed increased GFC in the overlapped brain areas, including the bilateral insula, right inferior parietal lobule (IPL), and right supramarginal gyrus\/IPL. By contrast, decreased GFC in the overlapped brain areas, including the bilateral posterior cingulate cortex\/presuneus and left calcarine cortex, was found in patients with MDD. In addition, patients with schizophrenia in Sample 3 did not show any GFC abnormalities in the overlapped areas from the results of Samples 1 and 2. The present study is the first to examine voxel\u2010wise brain\u2010wide FC in MDD with two independent samples by using an overlapping technique. The results indicate that aberrant FC patterns of insula\u2010centered sensorimotor circuit may account for the pathophysiology of MDD.<\/jats:p>","DOI":"10.1002\/ajmg.b.32633","type":"journal-article","created":{"date-parts":[[2018,4,28]],"date-time":"2018-04-28T07:35:15Z","timestamp":1524900915000},"page":"447-453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Voxel\u2010wise brain\u2010wide functional connectivity abnormalities in first\u2010episode, drug\u2010naive patients with major depressive disorder"],"prefix":"10.1002","volume":"177","author":[{"given":"Xilong","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Psychiatry the Second Xiangya Hospital of Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jindong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry the Second Xiangya Hospital of Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangrong","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Psychiatry the Second Xiangya Hospital of Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renrong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry the Second Xiangya Hospital of Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhikun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Mental Health Center, the Second Affiliated Hospital, Guangxi Medical University Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huafu","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingping","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry the Second Xiangya Hospital of Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2949-4943","authenticated-orcid":false,"given":"Wenbin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry the Second Xiangya Hospital of Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.02.021"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2007.12.007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2009.02030.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23843"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4324\/9780203774441"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2482"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2016.12.005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)01020-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.04.027"},{"volume-title":"Structured clinical interview for DSM\u2010IV axis I disorders (SCID)","year":"1997","author":"First M. 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