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In this general population\u2010based prospective cohort study, the longitudinal associations between BDNF\u2010Val66Met polymorphism and the different levels of the extended psychosis phenotype were investigated. Addresses were contacted in a multistage clustered probability sampling frame covering 11 districts and 302 neighborhoods at baseline (<jats:italic>n<\/jats:italic>\u2009=\u20094011). A nested case\u2010control study (<jats:italic>n<\/jats:italic>\u2009=\u2009366) recruited individuals with PEs and PDs as well as individuals with no psychotic symptoms. In this subgroup, blood sampling for genetic analysis and assessment of environmental exposures were carried out, followed by clinical re\u2010appraisal at follow\u2010up 6 years later (<jats:italic>n<\/jats:italic>\u2009=\u2009254). The BDNF\u2010Val66Met polymorphism was significantly associated with the extended psychosis phenotype. The pattern of the association was that the BDNF\u2010Val66Met polymorphism impacted in a dose\u2010response but extra\u2010linear fashion, with stronger impact at the PD end of the extended psychosis phenotype. Associations were still significant after adjusting for sociodemographic factors and environmental exposures including life events, childhood adversity, socioeconomic status, urbanicity, and cannabis use. The BDNF\u2010Val66Met polymorphism may index susceptibility to expression of psychosis along a spectrum.<\/jats:p>","DOI":"10.1002\/ajmg.b.32641","type":"journal-article","created":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T02:15:21Z","timestamp":1526955321000},"page":"113-121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Is BDNF\u2010Val66Met polymorphism associated with psychotic experiences and psychotic disorder outcome? 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