{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:15:26Z","timestamp":1788293726056,"version":"build-2803163510"},"reference-count":62,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T00:00:00Z","timestamp":1533168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>Joint hypermobility (JH) is a common, though largely ignored physical trait with increasing clinical reverberations. A few papers suggest a link between JH and selected neurodevelopmental disorders, such as developmental coordination disorder (DCD). JH is also the hallmark of various hereditary connective tissue disorders (HCTDs). Children with HCTDs may present abnormal neurodevelopment but its manifestations remain undetermined. This study examined 23 children (group 1), aged 4\u201313 years, with different HCTDs (i.e., 19 with hypermobile Ehlers\u2010Danlos syndrome (EDS)\/hypermobility spectrum disorder, 3 with molecularly confirmed classical EDS, and 1 with Loeys\u2010Dietz syndrome type 1 due to <jats:italic>TGFBR2<\/jats:italic> mutation) and 23, age\u2010 and sex\u2010matched children with DCD (group 2). All underwent 14 different psychometric tests exploring motor, cognitive, executive\u2010attentive, and emotional\u2010behavior features. In group 1, 30%, 22%, and 13% patients presented DCD (with or without dysgraphia), learning disabilities, and attention deficit\u2010hyperactivity disorder, respectively. None had cognitive delay. In group 2, 17% patients presented generalized JH and none had HCTDs. DCD children presented more motor and coordination troubles than HCTDs patients, while quality of life of children with HCTDs resulted more deteriorated due to somatic manifestations and behavioral traits. This study presents the full overview of neurodevelopmental attributes in HCTDs, and compares with standardized tools the neurodevelopmental profile of children with DCD and HCTDs. While the high rate of neurodevelopmental comorbidities in HCTDs deserves attention, the impact of a dysfunctional connective tissue in children with a primary diagnosis of DCD needs more research.<\/jats:p>","DOI":"10.1002\/ajmg.b.32646","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T14:15:38Z","timestamp":1533305738000},"page":"546-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Exploring relationships between joint hypermobility and neurodevelopment in children (4\u201313 years) with hereditary connective tissue disorders and developmental coordination disorder"],"prefix":"10.1002","volume":"177","author":[{"given":"Caterina","family":"Piedimonte","sequence":"first","affiliation":[{"name":"Division of Child Neurology and Psychiatry, Department of Human Neurosciences Sapienza University of Rome, Policlinico Umberto I Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Penge","sequence":"additional","affiliation":[{"name":"Division of Child Neurology and Psychiatry, Department of Human Neurosciences Sapienza University of Rome, Policlinico Umberto I Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Morlino","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Genetics, Department of Molecular Medicine Sapienza University of Rome, San Camillo\u2010Forlanini Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Sperduti","sequence":"additional","affiliation":[{"name":"Biostatistics IRCCS\u2010San Gallicano Dermatologic Institute Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Terzani","sequence":"additional","affiliation":[{"name":"Division of Child Neurology and Psychiatry, Department of Human Neurosciences Sapienza University of Rome, Policlinico Umberto I Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Giannini","sequence":"additional","affiliation":[{"name":"Division of Child Neurology and Psychiatry, Department of Human Neurosciences Sapienza University of Rome, Policlinico Umberto I Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Colombi","sequence":"additional","affiliation":[{"name":"Division of Biology and Genetics, Department of Molecular and Translational Medicine, School of Medicine University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Grammatico","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Genetics, Department of Molecular Medicine Sapienza University of Rome, San Camillo\u2010Forlanini Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cardona","sequence":"additional","affiliation":[{"name":"Division of Child Neurology and Psychiatry, Department of Human Neurosciences Sapienza University of Rome, Policlinico Umberto I Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6069-0993","authenticated-orcid":false,"given":"Marco","family":"Castori","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics IRCCS\u2010Casa Sollievo della Sofferenza San Giovanni Rotondo FG Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,2]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Achenbach T. 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