{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:39:30Z","timestamp":1792143570522,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T00:00:00Z","timestamp":1539820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>Differential DNA methylation of the hypothalamic\u2010pituitary\u2010adrenal axis related gene <jats:italic>FKBP5<\/jats:italic> has recently been shown to be associated with varying response to environmental influences and may play a role in how well people respond to psychological treatments. Participants (<jats:italic>n<\/jats:italic>\u2009=\u2009111) received exposure\u2010based cognitive behavioural therapy (CBT) for agoraphobia with or without panic disorder, or specific phobias. Percentage DNA methylation levels were measured for the promoter region and intron 7 of <jats:italic>FKBP5<\/jats:italic>. The association between percentage reduction in clinical severity and change in DNA methylation was tested using linear mixed models. The effect of genotype (rs1360780) was tested by the inclusion of an interaction term. The association between change in DNA methylation and <jats:italic>FKBP5<\/jats:italic> expression was examined. Change in percentage DNA methylation at one CpG site of intron 7 was associated with percentage reduction in severity (\u03b2\u2009=\u2009\u22124.26, <jats:italic>p<\/jats:italic>\u2009=\u20093.90 \u00d7 10<jats:sup>\u22124<\/jats:sup>), where a decrease in DNA methylation was associated with greater response to therapy. An interaction was detected between rs1360780 and changes in DNA methylation in the promoter region of <jats:italic>FKBP5<\/jats:italic> on treatment outcome (<jats:italic>p<\/jats:italic>\u2009=\u2009.045) but did not survive correction for multiple testing. Changes in DNA methylation were not associated with <jats:italic>FKBP5<\/jats:italic> expression. Decreasing DNA methylation at one CpG site of intron 7 of <jats:italic>FKBP5<\/jats:italic> was strongly associated with decreasing anxiety severity following exposure\u2010based CBT. In addition, there was suggestive evidence that allele\u2010specific methylation at the promoter region may also be associated with treatment response. The results of this study add to the growing literature demonstrating the role of biological processes such as DNA methylation in response to environmental influences.<\/jats:p>","DOI":"10.1002\/ajmg.b.32650","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T09:01:24Z","timestamp":1539853284000},"page":"150-158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["DNA methylation of FKBP5 and response to exposure\u2010based psychological therapy"],"prefix":"10.1002","volume":"180","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2616-2644","authenticated-orcid":false,"given":"Susanna","family":"Roberts","sequence":"first","affiliation":[{"name":"King's College London, Social, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, Psychology and Neuroscience  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Keers","sequence":"additional","affiliation":[{"name":"King's College London, Social, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, Psychology and Neuroscience  London United Kingdom"},{"name":"Queen Mary University of London School of Biological and Chemical Sciences  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerome","family":"Breen","sequence":"additional","affiliation":[{"name":"King's College London, Social, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, Psychology and Neuroscience  London United Kingdom"},{"name":"National Institute for Health Research Biomedical Research Centre South London and Maudsley National Health Service Trust  United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6759-0944","authenticated-orcid":false,"given":"Jonathan R. 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