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The present study sought to use existing summary\u2010level data from previous genome\u2010wide association studies to determine if commonly varying single nucleotide polymorphisms are shared between psychiatric and immune\u2010related phenotypes. We estimated heritability and examined pair\u2010wise genetic correlations using the linkage disequilibrium score regression (LDSC) and heritability estimation from summary statistics methods. Using LDSC, we observed significant genetic correlations between immune\u2010related disorders and several psychiatric disorders, including anorexia nervosa, attention deficit\u2010hyperactivity disorder, bipolar disorder, major depression, obsessive compulsive disorder, schizophrenia, smoking behavior, and Tourette syndrome. Loci significantly mediating genetic correlations were identified for schizophrenia when analytically paired with Crohn's disease, primary biliary cirrhosis, systemic lupus erythematosus, and ulcerative colitis. We report significantly correlated loci and highlight those containing genome\u2010wide associations and candidate genes for respective disorders. We also used the LDSC method to characterize genetic correlations among the immune\u2010related phenotypes. We discuss our findings in the context of relevant genetic and epidemiological literature, as well as the limitations and caveats of the study.<\/jats:p>","DOI":"10.1002\/ajmg.b.32652","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T13:07:35Z","timestamp":1539695255000},"page":"641-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":213,"title":["Genetic correlations among psychiatric and immune\u2010related phenotypes based on genome\u2010wide association data"],"prefix":"10.1002","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7579-6096","authenticated-orcid":false,"given":"Daniel S.","family":"Tylee","sequence":"first","affiliation":[{"name":"Psychiatric Genetic Epidemiology &amp; Neurobiology Laboratory (PsychGENe Lab), Departments of Psychiatry and Behavioral Sciences &amp; Neuroscience and Physiology SUNY Upstate Medical University  Syracuse New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayin","family":"Sun","sequence":"additional","affiliation":[{"name":"Psychiatric Genetic Epidemiology &amp; 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