{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T10:51:08Z","timestamp":1778669468285,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T00:00:00Z","timestamp":1542931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>The 2017 nosology defines the new criteria for hypermobile Ehlers\u2013Danlos syndrome (hEDS), which is now considered one end of a continuous spectrum encompassing isolated, nonsyndromic joint hypermobility (JH) and hypermobility spectrum disorders (HSDs). Preliminary data indicate a link between JH and neurodevelopmental disorders and, in particular, developmental coordination disorder (DCD) in children. Assessing DCD in adults is difficult and the recently described functional difficulties questionnaire 9 (FDQ\u20109) is one of the few available tools. The aims of this study are to (a) validate FDQ\u20109 written in Italian and present normal values in 230 Italian controls; (b) explore the relationship of FDQ\u20109 with the brief pain inventory, composite autonomic symptom score 31, multidimensional fatigue inventory, attention deficit\/hyperactivity disorder self\u2010report version 1.1, and the SF\u201036 for quality of life in 105 Italian adults with hEDS\/HSD. Validation of the FDQ\u20109 in Italian was carried out by translation, cross\u2010cultural adaptation and test\/retest reliability analysis. A case\u2013control study was performed comparing the FDQ\u20109 outcome between 105 patients and 105 sex\u2010 and age\u2010matched controls. Fifty\u2010nine percent of the patients resulted positive compared to the 3.8% of controls (<jats:italic>p<\/jats:italic> value &lt; .00001). In patients, FDQ\u20109 positive result associated with positive attention deficit\/hyperactivity disorder self\u2010report version 1.1 (OR\u2009= 4.04). Multivariate regression analysis comparing FDQ\u20109 with the other questionnaires demonstrated a strong association between positive FDQ\u20109 and the number of painful joints. Our preliminary data open wider management and therapeutic perspectives for coordination difficulties in hypermobile individuals.<\/jats:p>","DOI":"10.1002\/ajmg.b.32698","type":"journal-article","created":{"date-parts":[[2018,11,24]],"date-time":"2018-11-24T04:29:12Z","timestamp":1543033752000},"page":"25-34","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Italian validation of the functional difficulties questionnaire (FDQ\u20109) and its correlation with major determinants of quality of life in adults with hypermobile Ehlers\u2013Danlos syndrome\/hypermobility spectrum disorder"],"prefix":"10.1002","volume":"180","author":[{"given":"Silvia","family":"Morlino","sequence":"first","affiliation":[{"name":"Laboratory of Medical Genetics, Department of Molecular Medicine Sapienza University of Rome  Rome Italy"},{"name":"\u201cVaclav Vojta\u201d Rehabiliation Center  Rome 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