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This knowledge is enabling clinicians, researchers, and direct\u2010to\u2010consumer genetics companies to conduct disease susceptibility testing based on powerful methods such as polygenic risk scoring. However, these technologies raise a set of complex ethical, legal, social, and policy considerations. Here we review and discuss a series of ethical dilemmas associated with susceptibility genetic testing for the two most common late\u2010onset neurodegenerative diseases, Alzheimer's and Parkinson's disease, including testing in asymptomatic individuals. Among others, these include informed consent, disclosure of results and unexpected findings, mandatory screening, privacy and confidentiality, and stigma and genetic discrimination. Importantly, appropriate counseling is a deciding factor for the ethical soundness of genetic testing, which poses a challenge for the regulation of these tests and the training of healthcare professionals. As genetic knowledge about these diseases continues growing and genetic testing becomes more widespread, it is increasingly important to raise awareness among researchers, medical practitioners, genetic counselors, and decision makers about the ethical, legal, and social issues associated with genetic testing for polygenic diseases.<\/jats:p>","DOI":"10.1002\/ajmg.b.32699","type":"journal-article","created":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T07:44:54Z","timestamp":1544168694000},"page":"609-621","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Ethical issues in susceptibility genetic testing for late\u2010onset neurodegenerative diseases"],"prefix":"10.1002","volume":"180","author":[{"given":"Amaranta","family":"Manrique de Lara","sequence":"first","affiliation":[{"name":"Licenciatura en Ciencias Gen\u00f3micas, Instituto de Biotecnolog\u00eda y Centro de Ciencias Gen\u00f3micas Universidad Nacional Aut\u00f3noma de M\u00e9xico  Cuernavaca Morelos Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Soto\u2010G\u00f3mez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Jur\u00eddicas Universidad Nacional Aut\u00f3noma de M\u00e9xico  Coyoac\u00e1n, Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"N\u00fa\u00f1ez\u2010Acosta","sequence":"additional","affiliation":[{"name":"Oficina de Informaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica para el Congreso de la Uni\u00f3n (INCyTU) Foro Consultivo Cient\u00edfico y Tecnol\u00f3gico, A.C.  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