{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:52:52Z","timestamp":1787165572223,"version":"build-2736575974"},"reference-count":95,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T00:00:00Z","timestamp":1544486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009658","name":"American Pain Society","doi-asserted-by":"publisher","award":["Future Leaders in Pain Grant"],"award-info":[{"award-number":["Future Leaders in Pain Grant"]}],"id":[{"id":"10.13039\/100009658","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K01AR071504R01AR060852"],"award-info":[{"award-number":["K01AR071504R01AR060852"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001744","name":"Mayday Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001744","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>\n                    Co\u2010morbid chronic musculoskeletal pain (CMSP) and posttraumatic stress symptoms (PTSS) are frequent sequelae of motor vehicle collision, are associated with greater disability than either outcome alone, and are more prevalent in women than men. In the current study we assessed for evidence that gene transcripts originating from the X chromosome contribute to sex differences in vulnerability to CMSP and PTSS after motor vehicle collision. Nested samples were drawn from a longitudinal study of African American individuals, and CMSP (0\u201310 numeric rating scale) and PTSS (impact of events scale, revised) outcomes were assessed 6\u2009months following motor vehicle collision. Blood RNA were sequenced (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009101) and the relationship between X chromosome mRNA expression levels and co\u2010morbid CMSP and PTSS outcomes was evaluated using logistic regression analyses. A disproportionate number of peritraumatic X chromosome mRNA predicting CMSP and PTSS in women were genes previously found to escape X chromosome inactivation (11\/40,\n                    <jats:italic>z<\/jats:italic>\n                    \u2009=\u2009\u22122.9,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.004). Secondary analyses assessing gene ontology relationships between these genes identified an enrichment in genes known to influence neuronal plasticity. Further, the relationship of expression of two critical regulators of X chromosome inactivation, X\u2010inactive specific transcript (\n                    <jats:italic>XIST)<\/jats:italic>\n                    and Yin Yang 1\n                    <jats:italic>(YY1)<\/jats:italic>\n                    , was different in women developing CMSP and PTSS. Together, these data suggest that X chromosome genes that escape inactivation may contribute to sex differences in vulnerability to CMSP and PTSS after motor vehicle collision.\n                  <\/jats:p>","DOI":"10.1002\/ajmg.b.32706","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T08:17:24Z","timestamp":1544516244000},"page":"415-427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Genes known to escape X chromosome inactivation predict co\u2010morbid chronic musculoskeletal pain and posttraumatic stress symptom development in women following trauma exposure"],"prefix":"10.1002","volume":"180","author":[{"given":"Shan","family":"Yu","sequence":"first","affiliation":[{"name":"Institute for Trauma Recovery, University of North Carolina  Chapel Hill North Carolina"},{"name":"Department of Anesthesiology University of North Carolina  Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute for Trauma Recovery, University of North Carolina  Chapel Hill North Carolina"},{"name":"Department of Anesthesiology University of North Carolina  Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Pan","sequence":"additional","affiliation":[{"name":"Institute for Trauma Recovery, University of North Carolina  Chapel Hill North Carolina"},{"name":"Department of Anesthesiology University of North Carolina  Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Kurz","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Datner","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Albert Einstein Medical Center  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis L.","family":"Hendry","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Florida College of Medicine  Jacksonville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc\u2010Anthony","family":"Velilla","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Sinai Grace  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Lewandowski","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Henry Ford Hospital  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Pearson","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Detroit Receiving  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Domeier","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine St Joseph Mercy Health System  Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel A.","family":"McLean","sequence":"additional","affiliation":[{"name":"Institute for Trauma Recovery, University of North Carolina  Chapel Hill North Carolina"},{"name":"Department of Anesthesiology University of North Carolina  Chapel Hill North Carolina"},{"name":"Department of Emergency Medicine University of North Carolina  Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5295-7072","authenticated-orcid":false,"given":"Sarah D.","family":"Linnstaedt","sequence":"additional","affiliation":[{"name":"Institute for Trauma Recovery, University of North Carolina  Chapel Hill North Carolina"},{"name":"Department of Anesthesiology University of North Carolina  Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,11]]},"reference":[{"issue":"6","key":"e_1_2_7_2_1","first-page":"1229","article-title":"Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen\u2010receptor gene correlates with X chromosome inactivation","volume":"51","author":"Allen R. C.","year":"1992","journal-title":"American Journal of Human Genetics"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-015-0053-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2008.11.005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet127"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cm.21294"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-011-1011-z"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2011.11.012"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.220"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1997.01830230082012"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1366"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-071013-014100"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-94"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.08.013"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03479"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03479"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl483"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/522036"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-11-r122"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu564"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2004.01.003"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2003.07.010"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.153.4.773"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.131193098"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2005.05007.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00349-9"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(00)00017-8"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.179"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2005.04.010"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(96)03038-2"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2004.07.002"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-6163.2009.00229.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.10.014"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(12)60048-0"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0887-6185(92)90040-E"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmpt.2008.11.011"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040526"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn923"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.211"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.06.026"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2015.06.012"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2016.06.005"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(03)00175-1"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.09.057"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.02.034"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1614047113"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674379604100707"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2014.6.2.137"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090803"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-323"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-012222"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.9.6352"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2017.12.014"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5878"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-7967(01)00069-9"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000181276.49204.bb"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.10.016"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1118"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3360"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408681102"},{"issue":"26","key":"e_1_2_7_62_1","first-page":"1","article-title":"National hospital ambulatory medical care survey: 2007 emergency department summary","volume":"26","author":"Niska R.","year":"2010","journal-title":"National Health Statistics Reports"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.60.3.409"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1682\/JRRD.2003.09.0397"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201642195"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827b1aa1"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/379131a0"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.36.042902.092433"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2004.05.005"},{"key":"e_1_2_7_70_1","doi-asserted-by":"crossref","unstructured":"Richmond T. S. &Jacoby S.(2008). Emergency department trauma: The immediate aftermath of motor vehicle collisions. In: M. P. Duckworth T. Iezzi W. T. O'Donohue (Eds.) Motor Vehicle Collisions: Medical Psychosocial and Legal Consequences 1st ed. (pp.83\u2013106).San Diego CA:Elsevier.","DOI":"10.1016\/B978-0-08-045048-3.00005-1"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_2_7_72_1","unstructured":"Ryb G. E. Dischinger P. C. Read K. M. &Kufera J. A.(2009). PTSD after severe vehicular crashes. Paper presented at the Annals of Advances in Automotive Medicine\/Annual Scientific Conference."},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610204104"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001636"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200006000-00006"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23170"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi112"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.31212"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1159\/000112050"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12030"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005860000220"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.132.6.959"},{"issue":"1","key":"e_1_2_7_83_1","first-page":"19","article-title":"Circumstances of chronic pain onset: Relationship to pain description, coping and psychological distress","volume":"10","author":"Toomey T. C.","year":"1997","journal-title":"Pain Clinic"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2013.04.013"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24265"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01857677"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22026"},{"issue":"4","key":"e_1_2_7_88_1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1176\/ajp.156.4.589","article-title":"Acute and chronic posttraumatic stress disorder in motor vehicle accident victims","volume":"156","author":"Ursano R. J.","year":"1999","journal-title":"American Journal of Psychiatry"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1520113113"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-70990-1_10"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0340007"},{"issue":"2","key":"e_1_2_7_92_1","first-page":"369","article-title":"Pain extent and diagnosis: Development and validation of the regional pain scale in 12,799 patients with rheumatic disease","volume":"30","author":"Wolfe F.","year":"2003","journal-title":"The Journal of Rheumatology"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks461"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.051"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.2108\/zsj.30.1019"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13962"}],"container-title":["American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.b.32706","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.32706","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajmg.b.32706","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.32706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T21:26:38Z","timestamp":1694294798000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.b.32706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,11]]},"references-count":95,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1002\/ajmg.b.32706"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.b.32706","archive":["Portico"],"relation":{},"ISSN":["1552-4841","1552-485X"],"issn-type":[{"value":"1552-4841","type":"print"},{"value":"1552-485X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,11]]},"assertion":[{"value":"2018-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}