{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T08:02:23Z","timestamp":1770278543477,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autism (or autism spectrum disorder [ASD]) is an often disabling childhood neurologic condition of mostly unknown cause. It is commonly diagnosed at 3 or 4 years of age. We explored whether there was an association of any analytes measured by newborn screening tests with a later diagnosis of ASD. A database was compiled of 3\u20135 year\u2010old patients with any ASD diagnosis in the Texas Medicaid system in 2010\u20132012. Two controls (without any ASD diagnosis) were matched to each case by infant sex and birth year\/month. All study subjects were linked to their 2007\u20132009 birth and newborn screening laboratory records, including values for 36 analytes or analyte ratios. We examined the association of analytes\/ratios with a later diagnosis of ASD. Among 3,258 cases and 6,838 controls, seven analytes (e.g., 17\u2010hydroxyprogesterone, acylcarnitines) were associated with a later ASD diagnosis. In this exploratory study, an ASD diagnosis was associated with 7 of 36 newborn screening analytes\/ratios. These findings should be replicated in other population\u2010based datasets.<\/jats:p>","DOI":"10.1002\/ajmg.b.32728","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T08:23:34Z","timestamp":1556094214000},"page":"291-304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The association between newborn screening analytes and childhood autism in a Texas Medicaid population, 2010\u20132012"],"prefix":"10.1002","volume":"180","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8827-1881","authenticated-orcid":false,"given":"Mark A.","family":"Canfield","sequence":"first","affiliation":[{"name":"Birth Defects Epidemiology and Surveillance Branch Texas Department of State Health Services  Austin Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H.","family":"Langlois","sequence":"additional","affiliation":[{"name":"Birth Defects Epidemiology and Surveillance Branch Texas Department of State Health Services  Austin Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary W.","family":"Rutenberg","sequence":"additional","affiliation":[{"name":"Center for Analytics and Decision Support Texas Health and Human Services Commission  Austin Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy J.","family":"Mandell","sequence":"additional","affiliation":[{"name":"School of Community and Rural Health, University of Texas Health Science Center  Tyler Texas"},{"name":"Population Health, Office of Health Affairs, UT System  Austin Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Hua","sequence":"additional","affiliation":[{"name":"Center for Health Statistics Texas Department of State Health Services  Austin Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan","family":"Reilly","sequence":"additional","affiliation":[{"name":"Biochemistry and Genetics Branch, Laboratory Services Section Texas Department of State Health Services  Austin Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duke J.","family":"Ruktanonchai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Children's Institute of Pittsburgh  Pittsburgh Pennsylvania"},{"name":"Department of Psychiatry, Wesley Family Services  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice F.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Center for Analytics and Decision Support Texas Health and Human Services Commission  Austin Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Hunt","sequence":"additional","affiliation":[{"name":"Biochemistry and Genetics Branch, Laboratory Services Section Texas Department of State Health Services  Austin Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra","family":"Freedenberg","sequence":"additional","affiliation":[{"name":"Newborn Screening and Genetics Unit Texas Department of State Health Services  Austin Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Lee","sequence":"additional","affiliation":[{"name":"Biochemistry and Genetics Branch, Laboratory Services Section Texas Department of State Health Services  Austin Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F.","family":"Villanacci","sequence":"additional","affiliation":[{"name":"Environmental Epidemiology and Disease Registries Section Texas Department of State Health Services  Austin Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022999712639"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.48"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201700012"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1362361312467709"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1120210109"},{"key":"e_1_2_8_7_1","unstructured":"ChristensenD.L. BaioJ. Van Naarden BraunK. BilderD. CharlesJ. ConstantinoJ.N. \u2026 Yeargin\u2010Allsopp M. (2016). Centers for Disease Control and Prevention (CDC). Prevalence and characteristics of autism spectrum disorder among children aged 8 years\u2014Autism and Developmental Disabilities Monitoring Network 11 sites United States 2012. Morbidity and Mortality Weekly Report Surveillance Summaries 65 1\u201323."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0000000000000235"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1586"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-009-9453-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-009-0076-x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.143"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.051672"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.161.4.326"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-2583"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1657"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-013-1875-y"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2013.10.008"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.01.023"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1708"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-publhealth-031816-044318"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2012.11.032"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115101"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.12.108"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12993-014-0048-2"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.publhealth.28.021406.144007"},{"key":"e_1_2_8_27_1","first-page":"1","article-title":"A short review on the current understanding of autism spectrum disorders","volume":"25","author":"Park H. R.","year":"2016","journal-title":"Experimental Biology"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2010.136"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00150"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.004416"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/1362361315604076"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2017.4"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2004.03.008"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.2645"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2016.10.009"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1044\/0161-1461(2003\/015)"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.2707"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.01.004"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37144"}],"container-title":["American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.b.32728","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.32728","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajmg.b.32728","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.32728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T09:43:30Z","timestamp":1694339010000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.b.32728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,24]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1002\/ajmg.b.32728"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.b.32728","archive":["Portico"],"relation":{},"ISSN":["1552-4841","1552-485X"],"issn-type":[{"value":"1552-4841","type":"print"},{"value":"1552-485X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,24]]},"assertion":[{"value":"2018-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}