{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:44:05Z","timestamp":1763642645973,"version":"3.40.5"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673194"],"award-info":[{"award-number":["81673194"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Genome\u2010wide association studies (GWAS) of developmental dyslexia (DD) often used European samples and identified only a handful associations with moderate or weak effects. This study aims to identify DD functional variants by integrating the GWAS associations with tissue\u2010specific functional data and test the variants in a Chinese DD study cohort named READ. We colocalized associations from nine DD related GWAS with expression quantitative trait loci (eQTL) derived from brain tissues and identified two eSNPs rs349045 and rs201605. Both eSNPs had supportive evidence of chromatin interactions observed in human hippocampus tissues and their respective target genes <jats:italic>ZNF45<\/jats:italic> and <jats:italic>DNAH9<\/jats:italic> both had lower expression in brain tissues in schizophrenia patients than controls. In contrast, an eSNP rs4234898 previously identified based on eQTL from the lymphoblastic cell lines of dyslexic children had no chromatin interaction with its target gene <jats:italic>SLC2A3<\/jats:italic> in hippocampus tissues and <jats:italic>SLC2A3<\/jats:italic> expressed higher in the schizophrenia patients than controls. We genotyped the three eSNPs in the READ cohort of 372 cases and 354 controls and discovered only weak associations in rs201605 and rs4234898 with three DD symptoms (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The lack of associations could be due to low power in READ but could also implicate different etiology of DD in Chinese.<\/jats:p>","DOI":"10.1002\/ajmg.b.32750","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T09:43:57Z","timestamp":1562060637000},"page":"488-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Dyslexia associated functional variants in Europeans are not associated with dyslexia in Chinese"],"prefix":"10.1002","volume":"180","author":[{"given":"Lingfei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Maternal and Child Health and MOE (Ministry of Education) Key Laboratory of Environment and Health School of Public Health, Tongji Medical College, Huazhong University of Science and Technology  Wuhan 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