{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T10:23:09Z","timestamp":1792578189749,"version":"4.5.0"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Evidence from family and twin studies points to a genetic contribution to the etiology of eating disorders (EDs), confirmed by the association of several single nucleotide polymorphisms (SNPs) with this group of disorders. Previous reports have suggested that the serotonin receptor (<jats:italic>5\u2010HT2AR<\/jats:italic>) and brain\u2010derived neurotrophic factor (<jats:italic>BDNF<\/jats:italic>) genes could be both involved in EDs susceptibility. In order to provide further evidence about such association, we focused our attention on two SNPs located in these genes carrying out a genetic association study on a large Italian cohort composed of 556 ED patients and 355 controls (CTRs). Obtained results confirm the presence of an association between <jats:italic>5\u2010HT2AR<\/jats:italic> and <jats:italic>BDNF<\/jats:italic> genes and the susceptibility to EDs.<\/jats:p>","DOI":"10.1002\/ajmg.b.32771","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T10:10:38Z","timestamp":1574244638000},"page":"155-163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["<i>5\u2010HT2AR<\/i> and <i>BDNF<\/i> gene variants in eating disorders susceptibility"],"prefix":"10.1002","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5344-4890","authenticated-orcid":false,"given":"M. Rachele","family":"Ceccarini","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Science University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Tasegian","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marica","family":"Franzago","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging School of Medicine and Health Sciences, \u201cG. d'Annunzio\u201d University  Chieti\u2010Pescara Italy"},{"name":"Aging and Translational Medicine Research Center (CeSI\u2010MeT) University \u201cG. d'Annunzio\u201d  Chieti\u2010Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Filomena","family":"Patria","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Albi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Codini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"Conte","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bertelli","sequence":"additional","affiliation":[{"name":"MAGI Euregio, Non Profit Genetic Testing Laboratory, Research Unit  Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Dalla Ragione","sequence":"additional","affiliation":[{"name":"University of Campus Biomedico, Dipartimento di Scienze e Tecnologie per l'uomo e l'ambiente  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liborio","family":"Stuppia","sequence":"additional","affiliation":[{"name":"Aging and Translational Medicine Research Center (CeSI\u2010MeT) University \u201cG. d'Annunzio\u201d  Chieti\u2010Pescara Italy"},{"name":"Department of Psychological, Health and Territorial Sciences School of Medicine and Health Sciences, \"G. d'Annunzio\" University  Chieti\u2010Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Beccari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,20]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"163","article-title":"Decreased 5\u2010HT2a receptor binding in patients with anorexia nervosa","volume":"44","author":"Audenaert K.","year":"2003","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.187"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00280-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.3.305"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-108X(200001)27:1<1::AID-EAT1>3.0.CO;2-Q"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e3181646765"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173560"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)64135-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1997"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.16121402"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00035-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)78746-8"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-010-8138-2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNN.0000000000000028"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.9.1698"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.10.1916"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.08.025"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btf869"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/377003"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00812-8"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-013-0423-y"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1519"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22896"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.6.1290"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-9338(99)80741-X"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291701003725"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.05094.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.26.15239"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40519-016-0345-x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.08.001"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329170999122X"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2007.00301.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2009.03.011"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.07.040"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890252953473"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00859-9"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01746-8"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1012"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000304086.75913.b2"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)01107-0"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2011.0133"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2009.10.007"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh137"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201351"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)00088-5"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend.15.10.0706"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.20233"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1086\/321276"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2011.09.005"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-018-0931-x"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1383"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.09.028"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90048-5"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)78745-6"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0140525X00022871"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.3.393"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8046479"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0439-2"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00277"}],"container-title":["American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.32771","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajmg.b.32771","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.32771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T06:11:24Z","timestamp":1694067084000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.b.32771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,20]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/ajmg.b.32771"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.b.32771","archive":["Portico"],"relation":{},"ISSN":["1552-4841","1552-485X"],"issn-type":[{"value":"1552-4841","type":"print"},{"value":"1552-485X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,20]]},"assertion":[{"value":"2019-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}