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Few genome\u2010wide association studies (GWAS) examining ANX risk have been published and almost exclusively in individuals of European ancestry. In this study, we phenotyped participants from the Army Study To Assess Risk and Resilience in Servicemembers (STARRS) to approximate DSM\u2010based ANX diagnoses. We factor\u2010analyzed those to create a single dimensional anxiety score for each subject. GWAS were conducted using that score within each of three ancestral groups (EUR, AFR, LAT) and then meta\u2010analyzed across ancestries (<jats:italic>N<\/jats:italic><jats:sub>Total<\/jats:sub> =\u200916,510). We sought to (a) replicate prior ANX GWAS findings in ANGST; (b) determine whether results extended to other ancestry groups; and (c) meta\u2010analyze with ANGST for increased power to identify novel susceptibility loci. No reliable genome\u2010wide significant SNP associations were detected in STARRS. However, SNPs within the <jats:italic>CAMKMT<\/jats:italic> gene located in region 2p21 associated with shared ANX risk in ANGST were replicated in EUR soldiers but not other ancestry groups. Combining EUR STARRS and ANGST (<jats:italic>N<\/jats:italic> =\u200928,950) yielded a more robust 2p21 association signal (<jats:italic>p<\/jats:italic> =\u20099.08x10<jats:sup>\u221211<\/jats:sup>). Gene\u2010based analyses supported three genes within 2p21 and <jats:italic>LBX1<\/jats:italic> on chromosome 10. More powerful ANX genetic studies will be required to identify further loci.<\/jats:p>","DOI":"10.1002\/ajmg.b.32776","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T12:58:27Z","timestamp":1577710707000},"page":"197-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Genome\u2010wide association study of shared liability to anxiety disorders in Army STARRS"],"prefix":"10.1002","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0105-9034","authenticated-orcid":false,"given":"John M.","family":"Hettema","sequence":"first","affiliation":[{"name":"Department of Psychiatry Texas A&amp;M Health Sciences Center  Bryan Texas"},{"name":"Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry Virginia Commonwealth University  Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad","family":"Verhulst","sequence":"additional","affiliation":[{"name":"Department of Psychology Michigan State University  East Lansing Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Chatzinakos","sequence":"additional","affiliation":[{"name":"Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry Virginia Commonwealth University  Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silviu\u2010Alin","family":"Bacanu","sequence":"additional","affiliation":[{"name":"Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry Virginia Commonwealth University  Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Yen","family":"Chen","sequence":"additional","affiliation":[{"name":"Psychiatric and Neurodevelopmental Genetics Unit Center for Genomic Medicine, Massachusetts General Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Ursano","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Uniformed Services University  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C.","family":"Kessler","sequence":"additional","affiliation":[{"name":"Department of Healthcare Policy Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Gelernter","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Genetics, &amp; Neurobiology Yale University School of Medicine  New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan W.","family":"Smoller","sequence":"additional","affiliation":[{"name":"Psychiatric and Neurodevelopmental Genetics Unit Center for Genomic Medicine, Massachusetts General 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