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Here, we report a boy with a 2.58\u2010Mb de novo deletion at chromosome 15q24. He is diagnosed with ASD and having multiple phenotypes similar to those reported in cases having 15q24 microdeletion syndrome. To delineate the critical genes and region that might be responsible for these phenotypes, we reviewed all previously published cases. We observe a potential minimum critical region of 650\u2009kb (LCR15q24A\u2010B) affecting<jats:italic>NEO1<\/jats:italic>among other genes that might pertinent to individuals with ASD carrying this deletion. In contrast, a previously defined minimum critical region downstream of the 650\u2010kb interval (LCR15q24B\u2010D) is more likely associated with the developmental delay, facial dysmorphism, recurrent infection, and other congenital malformations. As a result, the ASD phenotype in this individual is potentially attributed by genes particularly<jats:italic>NEO1<\/jats:italic>within the newly proposed critical region.<\/jats:p>","DOI":"10.1002\/ajmg.b.32778","type":"journal-article","created":{"date-parts":[[2020,1,18]],"date-time":"2020-01-18T13:37:05Z","timestamp":1579354625000},"page":"217-226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Refining critical regions in 15q24 microdeletion syndrome pertaining to autism"],"prefix":"10.1002","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1298-492X","authenticated-orcid":false,"given":"Yi","family":"Liu","sequence":"first","affiliation":[{"name":"Pediatric Research Institute, Qilu Children's Hospital of Shandong University Ji'nan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pediatric Health Care Institute, Qilu Children's Hospital of Shandong University Ji'nan 250022 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Zarrei","sequence":"additional","affiliation":[{"name":"The Centre for Applied Genomics The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Dong","sequence":"additional","affiliation":[{"name":"Pediatric Research Institute, Qilu Children's Hospital of Shandong University Ji'nan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Pediatric Research Institute, Qilu Children's Hospital of Shandong University Ji'nan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Pediatric Health Care Institute, Qilu Children's Hospital of Shandong University Ji'nan 250022 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8326-1999","authenticated-orcid":false,"given":"Stephen W.","family":"Scherer","sequence":"additional","affiliation":[{"name":"The Centre for Applied Genomics The Hospital for Sick Children Toronto Ontario Canada"},{"name":"McLaughlin Centre and Department of Molecular Genetics University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongtao","family":"Gai","sequence":"additional","affiliation":[{"name":"Pediatric Research Institute, Qilu Children's Hospital of Shandong University Ji'nan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv069"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.945"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-014-1571-x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33097"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1985"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2011.11.006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00269"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12101"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115913"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.31188"},{"issue":"9","key":"e_1_2_8_12_1","first-page":"1501","article-title":"A novel case of 15q24 microdeletion syndrome detected by MLPA in a Chinese family","volume":"63","author":"Dai X. 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