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Electronic health records linked to genetic data provide an opportunity to test whether genetic scores for ADHD correlate with ADHD and additional health outcomes in a health care context across different age groups. We generated polygenic scores (ADHD\u2010PGS) trained on summary statistics from the latest genome\u2010wide association study of ADHD (<jats:italic>N<\/jats:italic>\u00a0=\u00a055,374) and applied them to genome\u2010wide data from 12,383 unrelated individuals of African\u2010American ancestry and 66,378 unrelated individuals of European ancestry from the Vanderbilt Biobank. Overall, only Tobacco use disorder (TUD) was associated with ADHD\u2010PGS in the African\u2010American ancestry group (Odds ratio [95% confidence intervals]\u00a0=\u00a01.23[1.16\u20131.31], <jats:italic>p<\/jats:italic>\u00a0=\u00a09.3\u2009\u00d7\u200910<jats:sup>\u221209<\/jats:sup>). Eighty\u2010six phenotypes were associated with ADHD\u2010PGS in the European ancestry individuals, including ADHD (OR[95%CIs]\u00a0=\u00a01.22[1.16\u20131.29], <jats:italic>p<\/jats:italic>\u00a0=\u00a03.6\u2009\u00d7\u200910<jats:sup>\u221210<\/jats:sup>), and TUD (OR[95%CIs]\u00a0=\u00a01.22[1.19\u20131.25], <jats:italic>p<\/jats:italic>\u00a0=\u00a02.8\u2009\u00d7\u200910<jats:sup>\u221246<\/jats:sup>). We then stratified outcomes by age (ages 0\u201311, 12\u201318, 19\u201325, 26\u201340, 41\u201360, and 61\u2013100). Our results suggest that ADHD polygenic scores are associated with ADHD diagnoses\u00a0early in life and with an increasing number of health conditions throughout the lifespan (even in the absence of ADHD diagnosis). This study reinforces the utility of applying trait\u2010specific PGSs to biobank data, and performing exploratory sensitivity analyses, to probe relationships among clinical conditions.<\/jats:p>","DOI":"10.1002\/ajmg.b.32911","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T06:55:20Z","timestamp":1657954520000},"page":"185-195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A phenome\u2010wide association study of polygenic scores\u00a0for attention deficit hyperactivity disorder across two genetic ancestries in electronic health record data"],"prefix":"10.1002","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8855-7393","authenticated-orcid":false,"given":"Maria","family":"Niarchou","sequence":"first","affiliation":[{"name":"Vanderbilt Genetics Institute Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Division of Genetic Medicine, Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia M.","family":"Sealock","sequence":"additional","affiliation":[{"name":"Vanderbilt Genetics Institute Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Straub","sequence":"additional","affiliation":[{"name":"Vanderbilt Genetics Institute Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Sanchez\u2010Roige","sequence":"additional","affiliation":[{"name":"Division of Genetic Medicine, Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Psychiatry University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Sutcliffe","sequence":"additional","affiliation":[{"name":"Vanderbilt Genetics Institute Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Psychiatry and Behavioral Sciences Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea K.","family":"Davis","sequence":"additional","affiliation":[{"name":"Vanderbilt Genetics Institute Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Division of Genetic Medicine, Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Psychiatry and Behavioral Sciences Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University  Nashville Tennessee USA"},{"name":"Department of Biomedical Informatics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41562-019-0757-5"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2005.10.009"},{"issue":"3","key":"e_1_2_14_4_1","first-page":"12","article-title":"The effects of attention\u2010deficit\/hyperactivity disorder on employment and household income","volume":"8","author":"Biederman J.","year":"2006","journal-title":"MedGenMed"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2018.11.008"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.10.053"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110212"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.112.123299"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14622200802443536"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3656"},{"key":"e_1_2_14_11_1","article-title":"Human genetics needs an antiracism plan","author":"Davis L. 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