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This study aimed to determine whether DNA methylation in <jats:italic>SLC6A4<\/jats:italic> changes after antidepressant treatment and whether it affects treatment response in patients with depression. Overall, 221 Korean patients with depression completed 6\u2009weeks of selective serotonin reuptake inhibitor (SSRI) monotherapy. DNA was extracted from venous blood pre\u2010 and post\u2010treatment, and DNA methylation was analyzed using polymerase chain reaction. We used Wilcoxon's signed\u2010rank test to verify the difference in methylation after treatment. Treatment response was assessed using the 17\u2010item Hamilton Depression Rating Scale, and mRNA levels were quantified.<\/jats:p><jats:p>After adjusting for relevant covariates, DNA methylation was significantly altered in specific CpG sites in <jats:italic>SLC6A4<\/jats:italic> (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001 in CpG3, CpG4, and CpG5) following 6\u2009weeks of treatment. Methylation change's magnitude (\u0394DNA methylation) after drug treatment was not associated with treatment response or mRNA level change. SSRI antidepressants can influence <jats:italic>SLC6A4<\/jats:italic> methylation in patients with depression. However, \u0394DNA methylation at CpG3, CpG4, and CpG5 in <jats:italic>SLC6A4<\/jats:italic> was not associated with treatment response. Future studies should investigate the integrative effect of other genetic variants and CpG methylation on gene transcription and antidepressant treatment response.<\/jats:p>","DOI":"10.1002\/ajmg.b.32921","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T11:59:58Z","timestamp":1662983998000},"page":"28-37","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Influence of antidepressant treatment on <scp><i>SLC6A4<\/i><\/scp> methylation in Korean patients with major depression"],"prefix":"10.1002","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0797-5516","authenticated-orcid":false,"given":"Young Kyung","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeseung","family":"Kim","sequence":"additional","affiliation":[{"name":"Statistics and Data Center Samsung Medical Center  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seonwoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Statistics and Data Center Samsung Medical Center  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5309-2143","authenticated-orcid":false,"given":"Shinn\u2010Won","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2302-6153","authenticated-orcid":false,"given":"Doh Kwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul South Korea"},{"name":"Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2019.05.007"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045813"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.52.4.750"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145713000710"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119061"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.focus.16407"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012201"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S146114571200020X"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S146114571400039X"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805493105"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001547"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32279-7"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/hdy.2010.54"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-79948-3_2011"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.04.024"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8260.1967.tb00530.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1529-1006.00008"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3230"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2013.01.006"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8929057"},{"issue":"4","key":"e_1_2_9_22_1","first-page":"1","article-title":"Practice guideline for the treatment of patients with major depressive disorder (revision). 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