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Its utility for genetic studies of mania or bipolar traits has not been fully examined. We psychometrically compared the MDQ to self\u2010reported bipolar disorder in participants from the United Kingdom National Institute of Health and Care Research Mental Health BioResource. We conducted genome\u2010wide association studies of manic symptom quantitative traits and symptom subgroups, derived from the MDQ items (<jats:italic>N<\/jats:italic>\u2009=\u200911,568\u201319,859). We calculated genetic correlations with bipolar disorder and other psychiatric and behavioral traits. The MDQ screener showed low positive predictive value (0.29) for self\u2010reported bipolar disorder. Neither concurrent nor lifetime manic symptoms were genetically correlated with bipolar disorder. Lifetime manic symptoms had a highest genetic correlation (<jats:italic>r<\/jats:italic><jats:sub>g<\/jats:sub>\u2009=\u20091.0) with posttraumatic stress disorder although this was not confirmed by within\u2010cohort phenotypic correlations (<jats:italic>r<\/jats:italic><jats:sub>p<\/jats:sub>\u2009=\u20090.41). Other significant genetic correlations included attention deficit hyperactivity disorder (<jats:italic>r<\/jats:italic><jats:sub>g<\/jats:sub>\u2009=\u20090.69), insomnia (<jats:italic>r<\/jats:italic><jats:sub>g<\/jats:sub>\u2009=\u20090.55), and major depressive disorder (<jats:italic>r<\/jats:italic><jats:sub>g<\/jats:sub>\u2009=\u20090.42). Our study adds to existing literature questioning the MDQ's validity and suggests it may capture symptoms of general distress or psychopathology, rather than hypomania\/mania specifically, in at\u2010risk populations.<\/jats:p>","DOI":"10.1002\/ajmg.b.32938","type":"journal-article","created":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T13:04:30Z","timestamp":1683983070000},"page":"147-160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Genetic examination of the Mood Disorder Questionnaire and its relationship with bipolar disorder"],"prefix":"10.1002","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5513-8902","authenticated-orcid":false,"given":"Jessica","family":"Mundy","sequence":"first","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"},{"name":"UK National Institute for Health and Care Research (NIHR) Biomedical Research Centre South London and Maudsley Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1267-8287","authenticated-orcid":false,"given":"Christopher","family":"H\u00fcbel","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"},{"name":"UK National Institute for Health and Care Research (NIHR) Biomedical Research Centre South London and Maudsley Hospital  London UK"},{"name":"National Centre for Register\u2010based Research, Aarhus Business and Social Sciences Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett N.","family":"Adey","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"},{"name":"UK National Institute for Health and Care Research (NIHR) Biomedical Research Centre South London and Maudsley Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9419-1009","authenticated-orcid":false,"given":"Helena L.","family":"Davies","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"},{"name":"UK National Institute for Health and Care Research (NIHR) Biomedical Research Centre South London and Maudsley Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3483-9907","authenticated-orcid":false,"given":"Molly R.","family":"Davies","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"},{"name":"UK National Institute for Health and Care Research (NIHR) Biomedical Research Centre South London and Maudsley Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6759-0944","authenticated-orcid":false,"given":"Jonathan R. 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