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To clarify this etiology, healthcare\u2010based data are leveraged to assess the influences on fibromyalgia in several domains. Prevalence is less than 1% of females in our population register data, and about 1\/10th that in males. Fibromyalgia often presents with co\u2010occurring conditions including back pain, rheumatoid arthritis, and anxiety. More comorbidities are identified with hospital\u2010associated biobank data, falling into three broad categories of pain\u2010related, autoimmune, and psychiatric disorders. Selecting representative phenotypes with published genome\u2010wide association results for polygenic scoring, we confirm genetic predispositions to psychiatric, pain sensitivity, and autoimmune conditions show associations with fibromyalgia, although these may differ by ancestry group. We conduct a genome\u2010wide association analysis of fibromyalgia in biobank samples, which did not result in any genome\u2010wide significant loci; further studies with increased sample size are necessary to identify specific genetic effects\u00a0on fibromyalgia. Overall, fibromyalgia appears to have strong clinical and likely genetic links to several disease categories, and could usefully be understood as a composite manifestation of these etiological sources.<\/jats:p>","DOI":"10.1002\/ajmg.b.32949","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T10:09:07Z","timestamp":1687169347000},"page":"171-182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Life is pain: Fibromyalgia as a nexus of multiple liability distributions"],"prefix":"10.1002","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7689-415X","authenticated-orcid":false,"given":"Arden","family":"Moscati","sequence":"first","affiliation":[{"name":"The Charles Bronfman Institute for Personalized Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4509-0428","authenticated-orcid":false,"given":"Annika B.","family":"Faucon","sequence":"additional","affiliation":[{"name":"Division of Genetic Medicine, Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Vanderbilt Genetics Institute Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cayetana","family":"Arnaiz\u2010Y\u00e9pez","sequence":"additional","affiliation":[{"name":"Division of Genetic Medicine, Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Larsson","family":"L\u00f6nn","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research Lund University  Lund Sweden"},{"name":"Department of Family Medicine and Community Health Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Department of Population Health Science and Policy Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Department of Functional Pathology, School of Medicine Center for Community\u2010based Healthcare Research and Education (CoHRE), Shimane University  Matsue Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research Lund University  Lund Sweden"},{"name":"Department of Family Medicine and Community Health Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Department of Population Health Science and Policy Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Department of Functional Pathology, School of Medicine Center for Community\u2010based Healthcare Research and Education (CoHRE), Shimane University  Matsue Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian M.","family":"Belbin","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Health Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Department of Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish","family":"Nadkarni","sequence":"additional","affiliation":[{"name":"The Charles Bronfman Institute for Personalized Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy H.","family":"Cho","sequence":"additional","affiliation":[{"name":"The Charles Bronfman Institute for Personalized Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Department of Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth J. 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