{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T07:49:04Z","timestamp":1753861744296,"version":"3.41.2"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the 19th century, psychiatric genetic studies typically utilized a generic category of \u201cinsanity.\u201d This began to change after 1899, with the publication of Kraepelin's 6th edition containing, among other disorders, his mature concept of dementia praecox (DP). We here review an article published by Ryssia Wolfsohn in 1907 from her dissertation at the University of Zurich entitled \u201cDie Heredit\u00e4t bei Dementia praecox\u201d (The Heredity of Dementia Praecox). This work, performed under the supervision of E. Bleuler, was to our knowledge the first formal genetic study of the then new diagnosis of DP. She investigated 550 DP probands admitted to the Burgh\u00f6lzli hospital with known information about their \u201cheredity burden.\u201d For most probands, she had information on parents, siblings, grandparents, and aunts\/uncles. Of these patients, only 10% had no psychiatric illness in their families. In the remaining probands, she found rates of the four major categories of psychopathology she investigated: mental illness\u201456%, nervous disorders\u201419%, peculiar personalities 12% and alcoholism 13%. Her most novel analyses compared either total familial burden or burden of her four forms of mental disorders on her DP probands divided by subtype and outcome. In neither of these analyses, did she find significant differences.<\/jats:p>","DOI":"10.1002\/ajmg.b.32953","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T10:05:55Z","timestamp":1689242755000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ryssia Wolfsohn's 1907 dissertation on \u201cthe heredity of dementia praecox\u201d"],"prefix":"10.1002","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8689-6570","authenticated-orcid":false,"given":"Kenneth S.","family":"Kendler","sequence":"first","affiliation":[{"name":"Virginia Institute of Psychiatric and Behavioral Genetics, and Department of Psychiatry Medical College of Virginia\/Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Klee","sequence":"additional","affiliation":[{"name":"Department of Germanic Languages and Literatures University of Toronto  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"volume-title":"Schizophrenie. Entstehung und Entwicklung eines psychiatrischen Krankheitsbilds um 1990","year":"2013","author":"Bernet B.","key":"e_1_2_8_2_1"},{"volume-title":"Die heredit\u00e4ren Beziehungen der Dementia praecox","year":"1910","author":"Berze J.","key":"e_1_2_8_3_1"},{"key":"e_1_2_8_4_1","first-page":"436","article-title":"Die Prognose der Dementia praecox (Schizophreniegruppe)","volume":"65","author":"Bleuler E.","year":"1908","journal-title":"Allgemeine Zeitschrift f\u00fcr Psychiatrie und Psychischgerichtliche Medizin"},{"volume-title":"Handbuch der Psychiatrie: Spezieller Teil 4","year":"1911","author":"Bleuler E.","key":"e_1_2_8_5_1"},{"key":"e_1_2_8_6_1","first-page":"19","article-title":"Mendelismus bei Psychosen, speziell bei der Schizophrenie","volume":"1","author":"Bleuler E.","year":"1917","journal-title":"Schweizer Archiv f\u00fcr Neurologie und Psychiatrie"},{"volume-title":"Similarit\u00e9 et Mend\u00e9lisme dans l'h\u00e9r\u00e9dit\u00e9 de la d\u00e9mence pr\u00e9coce et de la folie maniaque\u2010depressive\u2026","year":"1915","author":"Boven W.","key":"e_1_2_8_7_1"},{"key":"e_1_2_8_8_1","first-page":"336","article-title":"Die psycho\u2010neurotische erbliche Belastung der Geistesgesunden und der Geisteskranken. Eine statistisch\u2010kritische Untersuchung auf Grund eigener Beobachtungen. I. Teil","volume":"2","author":"Diem O.","year":"1905","journal-title":"Archiv f\u00fcr Rassen\u2010 und Gesellschaftsbiologie"},{"volume-title":"Die Verbreitung der Kraepelinischen Krankheitslehre im deutschen Sprachraum zwischen 1893 und 1912 an Beisouek der Dementia praecox","year":"2005","author":"Feldmann S.","key":"e_1_2_8_9_1"},{"key":"e_1_2_8_10_1","first-page":"119","article-title":"On heredity in dementia Praecox","volume":"55","author":"Ireland W.","year":"1909","journal-title":"Journal of Mental Science"},{"key":"e_1_2_8_11_1","first-page":"644","article-title":"On heredity in dementia Praecox","volume":"30","author":"Ireland W.","year":"1909","journal-title":"Alienist and Neurologist"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01838311"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713001578"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.20030326"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32865"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01763-9"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32819"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32832"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbac111"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02076258"},{"volume-title":"Psychiatrie: Ein Lehrbuch fur Studirende und Aerzte","year":"1899","author":"Kraepelin E.","key":"e_1_2_8_21_1"},{"volume-title":"Psychiatry: A textbook for students and physicians (translation of the 6th edition of Psychiatrie\u2010translator volume 1\u2010Helga Metoui). Volume 1 \u2013 General psychiatry","year":"1990","author":"Kraepelin E.","key":"e_1_2_8_22_1"},{"volume-title":"Psychiatry, a textbook for students and physicians (translation of the 6th edition of Psychiatrie\u2010translator volume 2\u2010Sabine Ayed). Volume 2 \u2013 Clinical psychiatry","year":"1990","author":"Kraepelin E.","key":"e_1_2_8_23_1"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0957154X14546606"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02897397"},{"volume-title":"Origins of Mendelism","year":"1985","author":"Olby R. C.","key":"e_1_2_8_26_1"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.126.7.983"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02865154"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02866172"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2010.01552.x"},{"key":"e_1_2_8_31_1","first-page":"347","article-title":"Die Heredit\u00e4t bei Dementia praecox","volume":"64","author":"Wolfsohn R.","year":"1907","journal-title":"Allgemeine Zeitschrift f\u00fcr Psychiatrie und Psychisch\u2010Gerichtliche Medizin"},{"volume-title":"Doctorate File","year":"1907","author":"Wolfsohn R.","key":"e_1_2_8_32_1"},{"key":"e_1_2_8_33_1","first-page":"597","article-title":"Die Heredit\u00e4t bei Dementia praecox","volume":"64","author":"WRD","year":"1908","journal-title":"American Journal of Insanity"}],"container-title":["American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.32953","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T05:45:15Z","timestamp":1704260715000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.b.32953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,13]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/ajmg.b.32953"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.b.32953","archive":["Portico"],"relation":{},"ISSN":["1552-4841","1552-485X"],"issn-type":[{"type":"print","value":"1552-4841"},{"type":"electronic","value":"1552-485X"}],"subject":[],"published":{"date-parts":[[2023,7,13]]},"assertion":[{"value":"2023-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e32953"}}