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Various psychiatric and neurological disorders have been reported in SMS, with most literature focusing on children and adolescents. To provide an overview of the current knowledge on this topic in adults with SMS, we performed a comprehensive scoping review of the relevant literature. Our findings suggest that many manifestations that are common in childhood persist into adulthood. Neuropsychiatric manifestations in adults with SMS include intellectual disability, autism spectrum\u2010 and attention deficit hyperactivity disorder\u2010related features, self\u2010injurious and physical aggressive behaviors, sleep\u2013wake disorders, and seizures. Findings of this review may facilitate optimization of management strategies in adults with SMS, and may guide future studies exploring late\u2010onset psychiatric and neurological comorbidities in SMS.<\/jats:p>","DOI":"10.1002\/ajmg.b.32956","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T05:34:35Z","timestamp":1692423275000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Psychiatric and neurological manifestations in adults with Smith\u2013Magenis syndrome: A scoping review"],"prefix":"10.1002","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7862-6319","authenticated-orcid":false,"given":"Dorinde","family":"Korteling","sequence":"first","affiliation":[{"name":"Child and Adolescent Psychiatry &amp; Psychosocial Care, Emma Children's Hospital, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7711-4812","authenticated-orcid":false,"given":"Jiska L. 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