{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:50:04Z","timestamp":1785541804303,"version":"3.56.0"},"reference-count":87,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["K23MH121669"],"award-info":[{"award-number":["K23MH121669"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["U01MH125062"],"award-info":[{"award-number":["U01MH125062"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["U01MH125050"],"award-info":[{"award-number":["U01MH125050"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["CNE E\u221226\/203.052\/2017"],"award-info":[{"award-number":["CNE E\u221226\/203.052\/2017"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["1R34AT010661\u20100"],"award-info":[{"award-number":["1R34AT010661\u20100"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012695","name":"Beatrice and Samuel A. Seaver Foundation","doi-asserted-by":"publisher","award":["R01MH124679"],"award-info":[{"award-number":["R01MH124679"]}],"id":[{"id":"10.13039\/100012695","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Obsessive\u2010compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long\u2010sought risk loci, but &gt;95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans\u2010ancestry INitiative for OCD genomics (LATINO,\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.latinostudy.org\">https:\/\/www.latinostudy.org<\/jats:ext-link>\n                    ). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5000 richly phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans\u2010ancestry genomic analyses to accelerate the identification of OCD risk loci, fine\u2010map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.\n                  <\/jats:p>","DOI":"10.1002\/ajmg.b.32962","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T01:39:44Z","timestamp":1699580384000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Latin American Trans\u2010ancestry INitiative for OCD genomics (LATINO): Study protocol"],"prefix":"10.1002","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9051-1557","authenticated-orcid":false,"given":"James J.","family":"Crowley","sequence":"first","affiliation":[{"name":"Department of Genetics University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"},{"name":"Department of Psychiatry University of North Carolina at Chapel Hill  Chapel Hill North Carolina 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