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One of valproate's suggested mechanisms of action involves the brain\u2010derived neurotrophic factor (<jats:italic>BDNF<\/jats:italic>), expressed in the brain areas regulating emotions, such as the prefrontal cortex. Nonetheless, data about the role of <jats:italic>BDNF<\/jats:italic> in LTTR and its implications in the structure of the dorsolateral prefrontal cortex (dlPFC) is scarce. We explore the association of <jats:italic>BDNF<\/jats:italic> variants and dorsolateral cortical thickness (CT) with LTTR to valproate in bipolar disorder type I (BDI). Twenty\u2010eight BDI patients were genotyped for <jats:italic>BDNF<\/jats:italic> polymorphisms rs1519480, rs6265, and rs7124442, and T1\u2010weighted 3D brain scans were acquired. LTTR to valproate was evaluated with Alda's scale. A logistic regression analysis was conducted to evaluate LTTR according to <jats:italic>BDNF<\/jats:italic> genotypes and CT. We evaluated CT differences by genotypes with analysis of covariance. LTTR was associated with <jats:italic>BDNF<\/jats:italic> rs1519480 and right dlPFC thickness. Insufficient responders with the CC genotype had thicker right dlPFC than TC and TT genotypes. Full responders reported thicker right dlPFC in TC and TT genotypes. In conclusion, different patterns of CT related to <jats:italic>BDNF<\/jats:italic> genotypes were identified, suggesting a potential biomarker of LTTR to valproate in our population.<\/jats:p>","DOI":"10.1002\/ajmg.b.32966","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T12:09:10Z","timestamp":1699013350000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of <scp><i>BDNF<\/i><\/scp> risk variant and dorsolateral cortical thickness with long\u2010term treatment response to valproate in type I bipolar disorder: An exploratory study"],"prefix":"10.1002","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9248-0472","authenticated-orcid":false,"given":"Alejandra Monserrat","family":"Rodr\u00edguez\u2010Ram\u00edrez","sequence":"first","affiliation":[{"name":"Departamento de Farmacogen\u00e9tica Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valente","family":"Cedillo\u2010R\u00edos","sequence":"additional","affiliation":[{"name":"Departamento de Im\u00e1genes Cerebrales Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7722-5940","authenticated-orcid":false,"given":"Marco Antonio","family":"Sanabrais\u2010Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Departamento de Farmacogen\u00e9tica Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Becerra\u2010Palars","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Servicios Cl\u00ednicos Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Hern\u00e1ndez\u2010Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Departamento de Farmacogen\u00e9tica Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiram","family":"Ortega\u2010Ort\u00edz","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Servicios Cl\u00ednicos Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7737-501X","authenticated-orcid":false,"given":"Beatriz","family":"Camarena\u2010Medellin","sequence":"additional","affiliation":[{"name":"Departamento de Farmacogen\u00e9tica Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-017-0093-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540260902962206"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291706008968"},{"issue":"3","key":"e_1_2_9_6_1","first-page":"25","article-title":"Predictors of response to divalproex and lithium","volume":"56","author":"Bowden C. 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