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The aim of this study is to assess the stress experienced by parents of individuals with Noonan syndrome and related conditions. Forty\u2010eight parents (20 fathers; 28 mothers), among the 31 recruited families, completed the Italian version of the Parenting Stress Index\u2013Short Form. Our study shows abnormally elevated scores (\u2265\u200985\u00b0 percentile) in 35.4% of parents. Data retrieved from subscales reveal a perception of a difficult child in 25% of cases, a dysfunctional parental\u2010child interaction in 20.8%, a general parental distress in 10.4% of cases, and an elevated overall stress in 18.8% of parents. Questionnaires as the Parenting Stress Index\u2013Short Form are valuable tools to evaluate stress in parents\/caregivers of children with RASopathies. Evaluation by professionals is fundamental to support parents and caregivers in managing stressors and to enhance their quality of life and relationships. To prevent stress escalation and parents' burnout, an early assessment to tailor a timely treatment should be introduced as soon as possible as good clinical practice.<\/jats:p>","DOI":"10.1002\/ajmg.b.33009","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T02:20:07Z","timestamp":1727490007000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Parenting Stress Index in Caregivers of Individuals With Noonan Syndrome"],"prefix":"10.1002","volume":"198","author":[{"given":"Lucrezia","family":"Perri","sequence":"first","affiliation":[{"name":"Center for Rare Disease and Birth Defects Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germana","family":"Viscogliosi","sequence":"additional","affiliation":[{"name":"Center for Rare Disease and Birth Defects Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Trevisan","sequence":"additional","affiliation":[{"name":"Center for Rare Disease and Birth Defects Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS  Rome Italy"},{"name":"Section of Genomic Medicine, Department of Life Sciences and Public Health Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"},{"name":"Medical Genetics Unit Department of Laboratory and Infectious Sciences, Fondazione Policlinico Univaersitario A. 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