{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:00:25Z","timestamp":1787839225954,"version":"build-2784847793"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006424","name":"F\u00e9d\u00e9ration pour la Recherche sur le Cerveau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006424","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019916","name":"Schweizerische Anorexia Nervosa Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007380","name":"Fondation de l'Avenir pour la Recherche M\u00e9dicale Appliqu\u00e9e","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Anorexia nervosa (AN) is a psychiatric disorder with an estimated heritability of around 70%. Although the largest meta\u2010analysis of genome\u2010wide association studies on AN identified independent risk\u2010conferring loci for the disorder, the molecular mechanisms underlying the genetic basis of AN remain to be elucidated. To investigate AN, we performed transcriptome profiling in peripheral blood mononuclear cells from 15 AN patients and 15 healthy controls. We validated our mean results in a mouse model of chronic food restriction, which mimics several aspects of AN. In this exploratory study, we identified 673 significantly differentially expressed genes in AN. Among these genes, we identified seven genes previously found to be dysregulated in IPSC\u2010derived neurons from AN individuals and the <jats:italic>Vanin\u20101<\/jats:italic> (<jats:italic>Vnn1<\/jats:italic>) gene, which appears to play an important role in the regulation of several metabolic pathways. We confirmed underexpression of <jats:italic>Vnn1<\/jats:italic>, particularly in the liver, in a mouse model of chronic food restriction. These results indicate that quantitative food restriction affects <jats:italic>Vnn1<\/jats:italic> expression, suggesting that this gene may contribute to the anorexic phenotype in the chronic food restriction mouse model as well as in patients with AN. We believe that this report highlights promising candidate genes and gene pathways for AN, and although we did not obtain a significant result in the replication cohort, it identifies Vnn1 as a potential biomarker that may be used as a molecular target to predict and\/or to understand AN.<\/jats:p>","DOI":"10.1002\/ajmg.b.33018","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T18:43:37Z","timestamp":1733942617000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Potential New Expression Biomarkers for Anorexia Nervosa"],"prefix":"10.1002","volume":"198","author":[{"given":"Camille","family":"Verebi","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine G\u00e9nomique des maladies de syst\u00e8me et d'organe, H\u00f4pital Cochin, Assistance Publique Centre Universit\u00e9 de Paris Cit\u00e9  Paris France"},{"name":"Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM UMR1266, Gorwood Team Universit\u00e9 de Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Lebrun","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM UMR1266, Gorwood Team Universit\u00e9 de Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine Vily","family":"Petit","sequence":"additional","affiliation":[{"name":"U1213 Nutrition, Diabetes and the Brain Institut national de la sant\u00e9 et de la recherche m\u00e9dicale  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Viltart","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM UMR1266, Gorwood Team Universit\u00e9 de Paris Cit\u00e9  Paris France"},{"name":"SCALab, UMR CNRS 9193, D\u00e9partement de Psychologie, Facult\u00e9 PsySEF Universit\u00e9 de Lille  Villeneuve d'Ascq France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philibert","family":"Duriez","sequence":"additional","affiliation":[{"name":"GHU Paris Psychiatrie et Neurosciences, CMME H\u00f4pital Sainte\u2010Anne  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Saint\u2010Pierre","sequence":"additional","affiliation":[{"name":"Genomic, Institut Cochin, Inserm  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Gorwood","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM UMR1266, Gorwood Team Universit\u00e9 de Paris Cit\u00e9  Paris France"},{"name":"SCALab, UMR CNRS 9193, D\u00e9partement de Psychologie, Facult\u00e9 PsySEF Universit\u00e9 de Lille  Villeneuve d'Ascq France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Ramoz","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM UMR1266, Gorwood Team Universit\u00e9 de Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5953-2728","authenticated-orcid":false,"given":"Thierry","family":"Bienvenu","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine G\u00e9nomique des maladies de syst\u00e8me et d'organe, H\u00f4pital Cochin, Assistance Publique Centre Universit\u00e9 de Paris Cit\u00e9  Paris France"},{"name":"Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM UMR1266, Gorwood Team Universit\u00e9 de Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0145\u20102134(02)00541\u20100"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20164"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msac158"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13\u20100788"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.15167\/2421\u20104248\/jpmh2022.63.2S3.2772"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102023\u2010077260"},{"key":"e_1_2_10_9_1","volume-title":"Eating Disorder Inventory\u20102: Professional Manual","author":"Garner D. 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