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However, the behavioral phenotype of people with mosaic Down syndrome (mDS) has not been well characterized. This study aimed to examine the prevalence of self\u2010report and caregiver\u2010report symptoms of depression and anxiety among a sample of 62 participants with mDS aged 12\u201346 and assess their association with the percentage of trisomy 21 in blood and\/or buccal mucosa cells. The overall MANCOVA revealed a significant effect of trisomy on the set of internalizing scales, controlling for age and gender (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.038, partial eta\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.22). However, follow\u2010up univariate analyses showed that the initial significant effect of trisomy on fear (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.049, partial eta\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.08) did not survive correction for multiple comparisons (adjusted\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.300). No other effects were significant. This study highlights the high occurrence of depression and anxiety symptoms in individuals with mDS and the need for routine assessment to optimize their care. It also demonstrates the ability of people with mDS to complete these evaluations, thereby supporting their inclusion in research studies\/clinical trials.\n                  <\/jats:p>","DOI":"10.1002\/ajmg.b.33022","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T02:17:50Z","timestamp":1737080270000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Internalizing Psychiatric Symptoms in People With Mosaicism for Trisomy 21"],"prefix":"10.1002","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8614-1645","authenticated-orcid":false,"given":"Ruth C.","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Psychiatry Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"D'Aguilar","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quinn","family":"Hurshman","sequence":"additional","affiliation":[{"name":"Department of Human &amp; Molecular Genetics Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebekah","family":"NailorZee","sequence":"additional","affiliation":[{"name":"Department of Human &amp; Molecular Genetics Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy P.","family":"York","sequence":"additional","affiliation":[{"name":"Department of Human &amp; Molecular Genetics Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3009-3730","authenticated-orcid":false,"given":"George","family":"Capone","sequence":"additional","affiliation":[{"name":"Kennedy Krieger Institute Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ananda B.","family":"Amstadter","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colleen","family":"Jackson\u2010Cook","sequence":"additional","affiliation":[{"name":"Department of Pathology Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.32072"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20294"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30097"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/19315864.2011.599917"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36052"},{"issue":"22","key":"e_1_2_12_7_1","first-page":"463","article-title":"Racial Disparities in Median Age at Death of Persons With Down Syndrome\u2014United States, 1968\u20101997","volume":"50","author":"Centers for Disease Control and Prevention (CDC)","year":"2001","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.161.5.671"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.182.4.347"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033\u20102909.131.4.483"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.chi.0000233158.21925.95"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.20159"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3828\/jlcds.2010.11"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/19315864.2020.1790702"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.32614\/RJ-2014-031"},{"key":"e_1_2_12_17_1","volume-title":"DM\u2010ID\u20102: Diagnostic Manual, Intellectual Disability: A Textbook of Diagnosis of Mental Disorders in Persons With Intellectual Disability","author":"Levitas A.","year":"2018"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102788.1994.tb00348.x"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102788.2007.00985.x"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12075"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102788.2003.00457.x"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102788.1996.792792.x"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053\u2010199110000\u201000004"},{"key":"e_1_2_12_24_1","volume-title":"Thompson & Thompson Genetics in Medicine","author":"Nussbaum R. 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