{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:08:13Z","timestamp":1790820493275,"version":"4.1.0"},"reference-count":71,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH128676"],"award-info":[{"award-number":["R01MH128676"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01MH125062"],"award-info":[{"award-number":["U01MH125062"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006924","name":"International OCD Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Polygenic risk scores (PRS) estimate individuals' genetic risk for developing multifactorial conditions. Recent genome\u2010wide association studies have enabled development of psychiatric PRS, which hold potential to streamline diagnosis and treatment of psychiatric conditions. As individuals with mental illness often identify concern about passing on psychiatric conditions as a key factor in family planning, some may also seek to use psychiatric PRS in reproductive decisions like childbearing or embryo selection for in\u00a0vitro fertilization. Despite calls for increased regulation, there remains no clinical consensus on the utility of psychiatric PRS in reproductive contexts. Therefore, we conducted semi\u2010structured interviews of adults with psychiatric conditions (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200929) to evaluate patient perspectives toward the tool's potential benefits and risks. Approximately half of participants would be interested in harnessing psychiatric PRS for reproductive purposes\u2014including embryo screening and family planning\u2014driven largely by desires to improve children's quality of life and seek empowerment while parenting. Others worried selecting against embryos with genetic risk for psychiatric disorders could exacerbate stigma. Regardless of personal stance, many noted using psychiatric PRS in reproductive decisions should be permissible for the general population. As psychiatric PRS continue to mature, patient views reported here can help inform their future in reproductive spaces.\n                  <\/jats:p>","DOI":"10.1002\/ajmg.b.70011","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T09:41:59Z","timestamp":1771407719000},"page":"338-348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Patient Perspectives on Psychiatric Polygenic Risk Scores in Reproductive Decision\u2010Making and Polygenic Embryo Screening"],"prefix":"10.1002","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5548-9275","authenticated-orcid":false,"given":"Lauren A.","family":"Ginn","sequence":"first","affiliation":[{"name":"Center for Medical Ethics and Health Policy Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda R.","family":"Merner","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Neurosurgery Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Page M.","family":"Trotter","sequence":"additional","affiliation":[{"name":"Center for Medical Ethics and Health Policy Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlynn P.","family":"Craig","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Neurosurgery Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail C.","family":"Martinez","sequence":"additional","affiliation":[{"name":"Center for Medical Ethics and Health Policy Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Luc\u00eda","family":"Battaglino","sequence":"additional","affiliation":[{"name":"Center for Bioethics Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorit","family":"Barlevy","sequence":"additional","affiliation":[{"name":"Center for Medical Ethics and Health Policy Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne M.","family":"Ayton","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6268-2965","authenticated-orcid":false,"given":"Takahiro","family":"Soda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Florida  Gainesville Florida USA"},{"name":"Center for Autism and Neurodevelopment University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7631-3703","authenticated-orcid":false,"given":"Eric A.","family":"Storch","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"L\u00e1zaro\u2010Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Neurosurgery Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6541-3904","authenticated-orcid":false,"given":"Stacey","family":"Pereira","sequence":"additional","affiliation":[{"name":"Center for Medical Ethics and Health Policy Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30372"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010024\u201003074\u20100"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gim.2025.101507"},{"key":"e_1_2_12_5_1","volume-title":"Research Methods in Anthropology: Qualitative and Quantitative Approaches","author":"Bernard H. 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