{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:48:45Z","timestamp":1789192125947,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Women with the\n                    <jats:italic>FMR1<\/jats:italic>\n                    premutation (PM) are at increased risk for fragile X\u2010associated conditions (FXPAC), including cognitive and psychiatric features collectively termed fragile X\u2010associated neuropsychiatric disorders (FXAND). This study is the first to systematically investigate cognitive and psychiatric features in Italian female premutation carriers (PCs). One hundred Italian women with the PM were stratified into four age\u2010groups (\u2264\u200940, 41\u201350, 51\u201364, and \u2265\u200965\u2009years). Cognitive performance was assessed using Raven's Standard Progressive Matrices (RSPM) and the Telephone Montreal Cognitive Assessment (T\u2010MoCA). Psychological symptoms were measured with standardized self\u2010report questionnaires, and psychiatric diagnoses were determined through the Structured Clinical Interview for DSM\u20105 (SCID\u20105) disorders. Cognitive scores were generally within the normal range; however, participants aged \u2265\u200965\u2009years performed significantly worse on both RSPM and T\u2010MoCA. SCID\u20105 interviews showed that 51% met criteria for at least one current psychiatric disorder, most commonly generalized anxiety (37%) and major depression (18%). Early\u2010life neurodevelopmental difficulties were frequently reported. Self\u2010report measures often underestimated clinical severity relative to interview findings. These findings underline significant psychiatric vulnerability in female PCs and emphasize the need for prevention and timely intervention, including routine psychiatric assessment in clinical care.\n                  <\/jats:p>","DOI":"10.1002\/ajmg.b.70014","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:12:55Z","timestamp":1773807175000},"page":"406-419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Psychiatric and Cognitive Features in Italian Women With the\n                    <scp>\n                      <i>FMR1<\/i>\n                    <\/scp>\n                    Premutation: A Comprehensive Assessment Using\n                    <scp>SCID<\/scp>\n                    \u20105 and Standardized Cognitive Measures"],"prefix":"10.1002","volume":"201","author":[{"given":"Federica Alice Maria","family":"Montanaro","sequence":"first","affiliation":[{"name":"Department of Education, Psychology, Communication University of Bari Aldo Moro  Bari Italy"},{"name":"Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology University of Bari Aldo Moro\/Pia Fond. Card. G. Panico  Tricase Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5029-8448","authenticated-orcid":false,"given":"Randi J.","family":"Hagerman","sequence":"additional","affiliation":[{"name":"UC Davis MIND Institute, UC Davis Health  Sacramento California USA"},{"name":"Department of Pediatrics, School of Medicine University of California Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Spano","sequence":"additional","affiliation":[{"name":"Department of Psychology and Health Science Pegaso University  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Tassone","sequence":"additional","affiliation":[{"name":"UC Davis MIND Institute, UC Davis Health  Sacramento California USA"},{"name":"Department of Biochemistry and Molecular Medicine, School of Medicine University of California Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0423-3242","authenticated-orcid":false,"given":"Giancarlo","family":"Logroscino","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology University of Bari Aldo Moro\/Pia Fond. Card. G. Panico  Tricase Italy"},{"name":"Department of Translational Biomedicine and Neurosciences (DiBraiN) University of Bari Aldo Moro  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bosco","sequence":"additional","affiliation":[{"name":"Department of Education, Psychology, Communication University of Bari Aldo Moro  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1352\/0895-8017(2004)109<237:PWACIM>2.0.CO;2"},{"key":"e_1_2_13_3_1","first-page":"118","volume-title":"Parenting Stress Index\u2010Short Form","author":"Abidin R. 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