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However, treatment outcomes vary widely, and a substantial proportion of patients do not achieve sufficient improvement. Robust predictors of individual differences in symptom change are currently lacking. Genetic differences have been suggested to play a role, but existing evidence is inconclusive. This study investigated the extent to which common genetic variants\u2014single nucleotide polymorphisms (SNPs)\u2014contribute to variability in symptom change. The sample was derived from the MULTI\u2010PSYCH and NORDiC cohorts, comprising 3113 adults and children treated with CBT for depression, panic disorder, social anxiety disorder, or OCD. We performed a genome\u2010wide association study (GWAS) of symptom change following CBT and estimated the proportion of variance attributed to SNPs. Secondary analyses included GWAS and SNP\u2010based heritability estimation of additional clinically relevant outcomes: pre\u2010 and post\u2010treatment symptom severity and remission status. 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