{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T03:27:45Z","timestamp":1786505265043,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005288","name":"Funda\u00e7\u00e3o Amaz\u00f4nia Paraense de Amparo \u00e0 Pesquisa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007382","name":"Universidade Federal do Par\u00e1","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007382","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt B"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Attention\u2010Deficit\/Hyperactivity Disorder (ADHD) is a highly heritable neurodevelopmental disorder; however, its genetic architecture remains poorly explored in Indigenous populations. This study aimed to analyze and characterize genetic variation in 11 genes (\n                    <jats:italic>ADGRL3, CDH8, DCC, DUSP6, FOXP1, FOXP2, MEF2C, PCDH7, SEMA6D, SORCS3,<\/jats:italic>\n                    and\n                    <jats:italic>ST3GAL3<\/jats:italic>\n                    ) previously implicated in ADHD, in an indigenous sample, comparing them with reference populations from the 1000 Genomes Project. Exome data from 64 individuals representing 12 Indigenous groups from the Brazilian Amazon were analyzed. Among the identified, 99 met the inclusion criteria. Four previously unreported variants in the developed reference datasets were identified in\n                    <jats:italic>ADGRL3<\/jats:italic>\n                    ,\n                    <jats:italic>DCC<\/jats:italic>\n                    , and\n                    <jats:italic>FOXP2<\/jats:italic>\n                    . Significant differences in allele frequencies were observed for 56 variants compared with continental populations. Multidimensional scaling analysis indicated genetic differentiation of the Indigenous group in relation to other populations. This study highlights the distinct genetic profile of Amazonian Indigenous populations, likely shaped by demographic and evolutionary processes such as genetic drift and founder effects. The identification of exclusive variants and marked allele frequency differences reinforces the importance of including historically underrepresented populations in genomic studies related to ADHD and neurodevelopment, contributing to a broader understanding of human genetic diversity.\n                  <\/jats:p>","DOI":"10.1002\/ajmg.b.70028","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T02:46:11Z","timestamp":1786502771000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic Variation in\n                    <scp>ADHD<\/scp>\n                    \u2010Related Risk Genes in an Indigenous Population of the Amazon"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7259-9225","authenticated-orcid":false,"given":"Hirlesson Paix\u00e3o","family":"de Matos","sequence":"first","affiliation":[{"name":"Centro de Pesquisas Oncol\u00f3gicas Universidade 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