{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:15:14Z","timestamp":1761707714766},"reference-count":71,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,5]],"date-time":"2004-10-05T00:00:00Z","timestamp":1096934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt C"],"published-print":{"date-parts":[[2004,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Significant progress has been made during the past decade in corrective gene therapy of the skin. This includes advances in vector technology, targeted gene expression, gene replacement, gene correction, and the availability of appropriate animal models for a variety of candidate diseases. While non\u2010viral integration of large genes such as essential basement membrane proteins has been mastered, new challenges such as the control of immune responses lie ahead of the research community. Among the first skin diseases, patients with junctional epidermolysis bullosa (JEB) and xeroderma pigmentosum (XP) will enter clinical trials. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.c.30038","type":"journal-article","created":{"date-parts":[[2004,10,5]],"date-time":"2004-10-05T22:01:25Z","timestamp":1097013685000},"page":"93-100","source":"Crossref","is-referenced-by-count":19,"title":["Gene therapy and the skin"],"prefix":"10.1002","volume":"131C","author":[{"given":"U.R.","family":"Hengge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Bardenheuer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/71901"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301862"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.152.3.645"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/104303403766682241"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/10430340152480276"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302221"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301886"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00626-2"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.152.3.651"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(89)90029-2"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.9.5196"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.11.5798"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1041"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1196-1263"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000065612"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301280"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2003.120105.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475x.2000.00452.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1998.9.9-1359"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103139200"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1297-1388"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1997.8538"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/74480"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-2254(199901\/02)1:1<31::AID-JGM3>3.0.CO;2-T"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.23.6877"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/12856"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.6.927"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/104303400750035771"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3300956"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301800"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-0016(03)00013-3"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1006\/mthe.2000.0118"},{"key":"e_1_2_10_34_1","first-page":"165","volume-title":"Gene therapy: Therapeutic mechanisms and strategies","author":"Hengge UR","year":"1999"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-56441-3"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0695-161"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118750"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1999.tb00392.x"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80436-5"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1997.8.17-2125"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/10430340050015932"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.19642.x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1995.tb05236.x"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.8.4356"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1987.01660260111026"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.3.1496-1504.2002"},{"key":"e_1_2_10_47_1","first-page":"3909","article-title":"Recapitulation of the cellular xeroderma pigmentosum\u2010variant phenotypes using short interfering RNA for DNA polymerase H","volume":"63","author":"Laposa RR","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1089\/104303400750035852"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0795-705"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12292254"},{"key":"e_1_2_10_51_1","unstructured":"MagnaldoT SarasinA.2003. Use of the CD24 marker gene for the selection of keratinocytes stem cells transformed by exogenous sequences. WO 03\/004655 A2."},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200316887"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12289716"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12090.x"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm766"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200317193"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301978"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.192247899"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00793.x"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120601"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.10061"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.10.5141"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.091484998"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3300711"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3300809"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/41917"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092436"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81530-5"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3300730"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1006\/mthe.2000.0074"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3300601"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/75568"}],"container-title":["American Journal of Medical Genetics Part C: Seminars in Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.c.30038","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.c.30038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T10:19:54Z","timestamp":1694600394000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.c.30038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10,5]]},"references-count":71,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,11,15]]}},"alternative-id":["10.1002\/ajmg.c.30038"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.c.30038","archive":["Portico"],"relation":{},"ISSN":["1552-4868","1552-4876"],"issn-type":[{"value":"1552-4868","type":"print"},{"value":"1552-4876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10,5]]}}}