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Prenatal and perinatal growth of the lung and vasculature are interdependent and their continued coordinated growth is critical for survival after birth in this patient population. Lung protection strategies appear to improve survival in newborns with diaphragmatic hernia, but a subset of infants remain who demonstrate sufficiently severe lung hypoplasia that we are unable to provide support long\u2010term after birth. Fetal intervention is a strategy designed to enhance fetal lung growth towards improving survival in this most severely affected group, though other therapies to enhance postnatal lung and vascular growth should be concurrently investigated. However, any of these interventions will require careful selection of those infants at risk for poor outcome and thorough follow up, since long\u2010term morbidity is significant in children with diaphragmatic hernia. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.c.30130","type":"journal-article","created":{"date-parts":[[2007,4,13]],"date-time":"2007-04-13T13:51:30Z","timestamp":1176472290000},"page":"184-200","source":"Crossref","is-referenced-by-count":36,"title":["Antenatal and postnatal lung and vascular anatomic and functional studies in congenital diaphragmatic hernia: Implications for clinical management"],"prefix":"10.1002","volume":"145C","author":[{"given":"Roberta L.","family":"Keller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0010010"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199811)18:11<1138::AID-PD416>3.0.CO;2-A"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/147.2.474"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.96.6.1117"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5325.230"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-005-1557-8"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.03.058"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.09.010"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.54.8.614"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.14030162.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.09.018"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70178-7"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199611)22:5<295::AID-PPUL2>3.0.CO;2-K"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200204-304CC"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.079392"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(93)90431-J"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.127130"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(98)90477-8"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.16.3.207"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.10.002"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(98)00327-3"},{"key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1542\/peds.40.4.709","article-title":"Neonatal pulmonary ischemia. 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