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We conducted in\u2010depth interviews with 18 young people who had undergone testing, to explore the range of harms and benefits that they perceived were associated with their tests. Participants were eight individuals who were tested for Huntington disease (two gene\u2010positive, six gene\u2010negative) and ten who were tested for familial adenomatous polyposis (five gene\u2010positive, five gene\u2010negative). At the time of their test they ranged from 10 to 25 years of age. When interviewed they ranged from 14 to 26 years of age. Harms described included knowledge of future illness, witnessing distress in parents, negative effects on family relationships and friendships, effects upon employment and school, experiencing regret, feeling guilty and having to confront difficult issues. Benefits included knowledge of gene\u2010negative status, relief from uncertainty, witnessing relief in parents, feeling able to plan for the future, positive effects on family relationships and friendships, feeling empowered and experiencing a sense of clarity about what is important in life. Harms were described in relation to gene\u2010negative test results, as were benefits in relation to gene\u2010positive test results. The testing process itself had several positive and negative effects for young people, distinct from the actual test result. Future research concerning the effects of predictive genetic testing in young people must remain broad and should aim to measure the beneficial as well as the harmful effects that resonate for young people themselves. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.c.30158","type":"journal-article","created":{"date-parts":[[2008,1,11]],"date-time":"2008-01-11T21:46:43Z","timestamp":1200088003000},"page":"47-55","source":"Crossref","is-referenced-by-count":77,"title":["\u201cYou're one of us now\u201d: Young people describe their experiences of predictive genetic testing for Huntington disease (HD) and familial adenomatous polyposis (FAP)"],"prefix":"10.1002","volume":"148C","author":[{"given":"Rony E.","family":"Duncan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Gillam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Savulescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin B.","family":"Delatycki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/302374"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2003.00157.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.6.1451"},{"key":"e_1_2_10_5_1","first-page":"1233","article-title":"Points to consider: Ethical, legal and psychosocial implications of genetic testing in children and adolescents","volume":"57","author":"American Society of Human Genetics Board of Directors and American College of Medical Genetics Board of Directors","year":"1995","journal-title":"Am J Hum Genet"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gim.0000245574.75877.b9"},{"key":"e_1_2_10_7_1","unstructured":"AndrewsL MireskandariS JessenJ ThewesB SolomonM MacraeF MeiserB.2007.Impact of familial adenomatous polyposis on young adults: Quality of life outcomes. 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