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Etiologies of gastroschisis are largely unknown, and even its pathogenesis is poorly understood. Several recent epidemiological studies have identified interactions between maternal smoking during pregnancy, genetic variants of endothelial nitric oxide synthase, and risk for gastroschisis. We present a brief review of the endothelial nitric oxide synthase pathway and its relationship to vasculogenesis, suggesting that disruption of this pathway by environmental exposures or by genetic variation may represent one pathogenetic model for gastroschisis. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.c.30182","type":"journal-article","created":{"date-parts":[[2008,7,25]],"date-time":"2008-07-25T05:05:32Z","timestamp":1216962332000},"page":"213-218","source":"Crossref","is-referenced-by-count":41,"title":["Gastroschisis: A gene\u2013environment model involving the VEGF\u2013NOS3 pathway"],"prefix":"10.1002","volume":"148C","author":[{"given":"Edward J.","family":"Lammer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David 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