{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T22:50:05Z","timestamp":1773096605396,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T00:00:00Z","timestamp":1423094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt C"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:label\/><jats:p>In the last decade, increasing attention has been devoted to the extra\u2010articular and extra\u2010cutaneous manifestations of joint hypermobility syndrome, also termed Ehlers\u2013Danlos syndrome, hypermobility type (i.e., JHS\/EDS\u2010HT). Despite the fact that the current diagnostic criteria for both disorders remain focused on joint hypermobility, musculoskeletal pain and skin changes, medical practice and research have started investigating a wide spectrum of visceral, neurological and developmental complications, which represent major burdens for affected individuals. In particular, children with generalized joint hypermobility often present with various neurodevelopmental issues and can be referred for neurological consultation. It is common that investigations in these patients yield negative or inconsistent results, eventually leading to the exclusion of any structural neurological or muscle disorder. In the context of specialized clinics for connective tissue disorders, a clear relationship between generalized joint hypermobility and a characteristic neurodevelopmental profile affecting coordination is emerging. The clinical features of these patients tend to overlap with those of developmental coordination disorder and can be associated with learning and other disabilities. Physical and psychological consequences of these additional difficulties add to the chief manifestations of the pre\u2010existing connective tissue disorder, affecting the well\u2010being and development of children and their families. In this review, particular attention is devoted to the nature of the link between joint hypermobility, coordination difficulties and neurodevelopmental issues in children. Presumed pathogenesis and management issues are explored in order to attract more attention on this association and nurture future clinical research. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.c.31424","type":"journal-article","created":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T04:01:57Z","timestamp":1423195317000},"page":"107-116","source":"Crossref","is-referenced-by-count":48,"title":["Neurodevelopmental attributes of joint hypermobility syndrome\/Ehlers\u2013Danlos syndrome, hypermobility type: Update and perspectives"],"prefix":"10.1002","volume":"169","author":[{"given":"Giulia","family":"Ghibellini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Brancati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Castori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh557"},{"key":"e_1_2_6_3_1","unstructured":"American Psychiatric Association.2000.DSM\u2010IV\u2010TR diagnostic and statistical manual of mental disorders.Washington DC:APA."},{"key":"e_1_2_6_4_1","unstructured":"2009 Thieme New York JC Arverdson B Heintskill MR McNeil Ehlers\u2010Danlos syndrome 314 316"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36060"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980428)77:1<31::AID-AJMG8>3.0.CO;2-O"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992287801701014"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35483"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36315"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2275-2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36805"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20434"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34330"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.4172\/2161\u20130673.S4\u2013001"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307389400900417"},{"key":"e_1_2_6_16_1","first-page":"47","article-title":"Generalized joint hypermobility and temporomandibular disorders: Inherited connective tissue disease as a model with maximum expression","volume":"19","author":"De Coster PJ","year":"2005","journal-title":"J Orofac Pain"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.12.006"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38505"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","unstructured":"EngelbertRH KoojimansFT van RietAM FeitsmaTM UiterwallCS HeldersPJ.2005. 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