{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:34:26Z","timestamp":1784871266765,"version":"3.55.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T00:00:00Z","timestamp":1427328000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt C"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:label\/><jats:p>This issue of the <jats:italic>American Journal of Medical Genetics Seminar Series Part C<\/jats:italic> is dedicated to generalized joint hypermobility (gJHM), joint hypermobility syndrome (JHS), and Ehlers\u2013Danlos syndrome, hypermobility type (EDS\u2010HT). gJHM is the best known clinical manifestation of inherited defects of the connective tissue. On the other side, JHS and EDS\u2010HT are actually considered one and the same from a clinical perspective by most practitioners and researchers (i.e., JHS\/EDS\u2010HT), and their molecular basis remains unknown. For decades, \u201cnon\u2010syndromic\u201d gJHM and JHS\/EDS\u2010HT have been thought to be simple clinical curiosities or an asset for the \u201caffected\u201d individual. In recent years, the attention on these partially overlapping phenotypes has increased, as they are now recognized risk factors for a series of non\u2010communicable diseases and long\u2010term disabilities. This series consists of 10 papers focused on three main topics, namely (i) assessment and differential diagnosis of children and adults with gJHM, (ii) systematic presentation of selected key non\u2010articular manifestations of JHS\/EDS\u2010HT and actual perception of physiotherapy as the best therapeutic resource for this condition, and (iii) exploration of the available knowledge relating \u201ccongenital laxity of tissues\u201d to various dysfunctions of the nervous system during development and adulthood. The contributors hope that this collection raises attention to this fascinating field of knowledge, which seems to have ramifications in virtually all medical disciplines. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.c.31432","type":"journal-article","created":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T22:37:36Z","timestamp":1427495856000},"page":"1-5","source":"Crossref","is-referenced-by-count":41,"title":["Generalized joint hypermobility, joint hypermobility syndrome and Ehlers\u2010Danlos syndrome, hypermobility type"],"prefix":"10.1002","volume":"169","author":[{"given":"Marco","family":"Castori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Colombi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,26]]},"container-title":["American Journal of Medical Genetics Part C: Seminars in Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.c.31432","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.c.31432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T02:46:07Z","timestamp":1694400367000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.c.31432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1002\/ajmg.c.31432"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.c.31432","archive":["Portico"],"relation":{},"ISSN":["1552-4868","1552-4876"],"issn-type":[{"value":"1552-4868","type":"print"},{"value":"1552-4876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3]]}}}