{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:26:10Z","timestamp":1770978370382,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T00:00:00Z","timestamp":1444348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt C"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:label\/><jats:p>Ehlers\u2013Danlos syndrome is a heterogeneous group of heritable connective tissue disorders characterized by increased fragility of various non\u2010ossified tissues. It is usually ascertained due to abnormal skin texture, scarring complications, vascular fragility, or chronic symptoms, such as fatigue and musculoskeletal pain. Sometimes, Ehlers\u2013Danlos syndrome remains undetected until the patient, usually in the pediatric age, shows extensive or severe mucocutaneous injuries after only minor traumas. In this scenario, the misdiagnosis of Ehlers\u2013Danlos syndrome with child abuse is a possibility, as occasionally reported in the literature. Recently, more attention was posed by lay people between the possible association of Ehlers\u2013Danlos syndrome and bone fragility. Literature and personal experience show a strong association between Ehlers\u2013Danlos syndrome, generalized joint hypermobility and reduced bone mass density in older children and adults, especially fertile women. The existence of a true increased risk of fracture in Ehlers\u2013Danlos syndrome is still a matter of debate in children and adults with little and conflicting evidence. In case of suspected child abuse, Ehlers\u2013Danlos syndrome is certainly on the differential for bruising, especially in EDS types with marked cutaneous and capillary involvement. In suspected child abuse cases, careful examination of the index case and her\/his extended family is routine, as well as exclusion of other disorders such as osteogenesis imperfecta. The hypothesis of Ehlers\u2013Danlos syndrome as an alternative explanation for infantile fractures remains speculative. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.c.31460","type":"journal-article","created":{"date-parts":[[2015,10,10]],"date-time":"2015-10-10T06:52:38Z","timestamp":1444459958000},"page":"289-292","source":"Crossref","is-referenced-by-count":30,"title":["Ehlers\u2013Danlos syndrome(s) mimicking child abuse: Is there an impact on clinical practice?"],"prefix":"10.1002","volume":"169","author":[{"given":"Marco","family":"Castori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,9]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/1947-2714.145482"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980070104"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/msc.184"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.53.3.212-b"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2012.01858.x"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.12.006"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.57.10.630"},{"key":"e_1_2_3_9_1","first-page":"799","article-title":"The relationship of joint hypermobility, bone mineral density, and osteoarthritis in the general population: The Chingford Study","volume":"30","author":"Dolan AL","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.111.092460"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.3.e248"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31424"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-005-0103-3"},{"key":"e_1_2_3_14_1","first-page":"1162","article-title":"Neuroimaging and psychophysiological investigation of the link between anxiety, enhanced affective reactivity and interoception in people with joint hypermobility","volume":"5","author":"Mallorqu\u00ed\u2010Bagu\u00e9 N","year":"2014","journal-title":"Front Psychol"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.3171\/SPI-07\/12\/601"},{"key":"e_1_2_3_16_1","first-page":"36","article-title":"Not a case of abuse","volume":"83","author":"Miller J","year":"1987","journal-title":"Nurs Times"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1984.01650370103020"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1984.tb04733.x"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006565-198509000-00010"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31430"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.7778"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33070"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-7-1"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2009.12.026"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2009.08.003"},{"key":"e_1_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/160.1.15"},{"key":"e_1_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01421.x"}],"container-title":["American Journal of Medical Genetics Part C: Seminars in Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.c.31460","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.c.31460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T02:47:32Z","timestamp":1694400452000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.c.31460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,9]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1002\/ajmg.c.31460"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.c.31460","archive":["Portico"],"relation":{},"ISSN":["1552-4868","1552-4876"],"issn-type":[{"value":"1552-4868","type":"print"},{"value":"1552-4876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,9]]}}}