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A growing body of literature implicates Adverse Childhood Experiences, including physical, sexual, and emotional abuse, in a broad range of negative health consequences including adult psychopathology, cardiovascular, and immune disease. Increasing evidence from animal, clinical, and epidemiological studies highlight the critical role of epigenetic programing, such as DNA methylation and histone modification, in altering gene expression, brain structure and function, and ultimately life\u2010course trajectories. This review outlines our developing insight into the interplay between our human biology and our changing environment, and explores the growing evidence base for how interventions may prevent and ameliorate damage inflicted by toxic stress in early life. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.c.31467","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T23:44:48Z","timestamp":1445903088000},"page":"353-360","source":"Crossref","is-referenced-by-count":28,"title":["Epigenetics and child abuse: Modern\u2010day darwinism \u2014 The miraculous ability of the human genome to adapt, and then adapt again"],"prefix":"10.1002","volume":"169","author":[{"given":"Naomi B.","family":"Gershon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela 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