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Recently, several new approaches have been devised that target whole chromosomes in vitro, which are collectively referred to as \u201cChromosome Therapies.\u201d These include silencing and selection for loss of the extra chromosome in trisomies, promotion of euploidy in an aneuploid culture, and forced loss and replacement of a chromosome. Here, we provide a review of Chromosome Therapy, and discuss potential directions for these methods clinically, as well as research applications and cellular models that can be made using these technologies. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.c.31530","type":"journal-article","created":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T05:02:49Z","timestamp":1478235769000},"page":"422-430","source":"Crossref","is-referenced-by-count":17,"title":["Chromosome therapy: Potential strategies for the correction of severe chromosome aberrations"],"prefix":"10.1002","volume":"172","author":[{"given":"Kathleen","family":"Plona","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taehyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Halloran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Wynshaw\u2010Boris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/dnares\/dsv016"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-12-108"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab1028"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8147"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12923"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/349038a0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03479"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03479"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171242"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1218933110"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2006.04.007"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad8856"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201619"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1237973"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320370706"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.05.003"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2013.04.004"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3728-10.2010"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-12-171"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphy.2014.00053"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2008.107"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-462002-5.50009-1"},{"key":"e_1_2_6_24_1","first-page":"179","volume-title":"Genetic disorders and the fetus","author":"Hsu LYF","year":"1998"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.05.010"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2008.08.008"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2015.05.006"},{"key":"e_1_2_6_28_1","unstructured":"ISSCR.2015. 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