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Somatic activating mutations in the PI3K\/AKT\/mTOR pathway are among the most common mutations identified in cancer, and have been shown to cause a spectrum of overgrowth syndromes including PIK3CA\u2010Related Overgrowth Spectrum, Proteus syndrome, and brain overgrowth conditions. Clinical findings in these disorders may be isolated or multiple, including sporadic or mosaic overgrowth (adipose, skeletal, muscle, brain, vascular, or lymphatic), and skin abnormalities (including epidermal nevi, hyper\u2010, and hypopigmented lesions), and have the potential risk of tumorigenesis. Key negative regulators of the PI3K\u2010AKT signaling pathway include PTEN and TSC1\/TSC2 and germline loss\u2010of function mutations of these genes are established to cause PTEN Hamartoma Tumor Syndrome and Tuberous Sclerosis Complex. Mosaic forms of these conditions lead to increased activation of PI3K and mTOR at affected sites and there is phenotypic overlap between these conditions. All are associated with significant morbidity with limited options for treatment other than symptomatic therapies and surgeries. As dysregulation of the PI3K\/AKT\/mTOR pathway has been implicated in cancer, several small molecule inhibitors targeting different components of the PI3K\/AKT\/mTOR signaling pathway are under clinical investigation. The development of these therapies brings closer the prospect of targeting treatment for somatic PI3K\/AKT\/mTOR\u2010related overgrowth syndromes. 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